TANK: TRAF family member associated NFKB activator
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1kzz chain B
1l0a chain B
5h10 chain D
5h10 chain E
5h10 chain F
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S49 REQQEQLS LQQTIID 1 10 - - - - - - - - 7 3 - - - - - - - - - - T68 QLLLVNST QDNNYGC 1 8 - - 4 4 - - - - - - - - - - - - - - - - Y73 NSTQDNNY GCVPLLE 3 35 9 - 4 4 - - - - - - - - 10 8 - - - - - - S82 CVPLLEDS ETRKNNL 5 176 - - 5 4 - - - - 11 7 35 32 18 17 - - - - 32 15 T90 ETRKNNLT LDQPQDK 1 6 - - - - - - - - - - - - - - - - - - 6 - S100 QPQDKVIS GIAREKL 1 18 - - - - - - - - - - - - 10 8 - - - - - - S116 KVRRQEVS SPRKETS 2 22 - - - - - - - - - - 9 8 - - - - 3 2 - - S117 VRRQEVSS PRKETSA 10 996 56 - 8 8 73 62 99 - 41 23 98 91 82 72 83 18 54 21 89 18 S126 RKETSARS LGSPLLH 9 253 6 - 4 4 - - 9 - 7 2 14 14 10 8 64 12 27 11 54 7 S129 TSARSLGS PLLHERG 10 1148 104 - 83 61 49 41 81 - 67 38 103 95 77 72 76 17 71 30 70 13
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S49 REQQEQLS LQQTIID - - - - - - - - - - - T68 QLLLVNST QDNNYGC - - - - - - - - - - - Y73 NSTQDNNY GCVPLLE - - - - - - - - - - - S82 CVPLLEDS ETRKNNL 5.7e-5 - - - - - 0.016 - - - 0.001 T90 ETRKNNLT LDQPQDK - - - - - - - - - - - S100 QPQDKVIS GIAREKL - - - - - - - - - - - S116 KVRRQEVS SPRKETS - - - - - - - - - - - S117 VRRQEVSS PRKETSA 4.1e-47 - - 4.2e-7 - 5.9e-6 6e-19 6.5e-17 1.5e-7 0.02 2.0e-4 S126 RKETSARS LGSPLLH 0.052 - - - - - - - 0.42 0.052 - S129 TSARSLGS PLLHERG 0.63 - 0.075 -0.38 - 0.36 -0.015 -8.5e-3 0.5 4.4e-5 -0.89
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S49
T68
Y73
S82
T90
S100
S116
S117
S126
S129
T175
S178
S208
T210
S211
T213
T224
S225
S228
T249
S257
S298
S348
S354
S357
S378
S380
S384
T386
S406
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation CCRCC S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation COAD S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation GBM S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation HNSCC S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation LSCC S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation LUAD S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation OV S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation PDAC S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation UCEC S49 T68 Y73 S82 T90 S100 S116 S117 S126 S129 T175 S178 S208 T210 S211 T213 T224 S225 S228 T249 S257 S298 S348 S354 S357 S378 S380 S384 T386 S406 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S49
T68
Y73
S82
T90
S100
S116
S117
S126
S129
T175
S178
S208
T210
S211
T213
T224
S225
S228
T249
S257
S298
S348
S354
S357
S378
S380
S384
T386
S406
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S49
T68
Y73
S82
T90
S100
S116
S117
S126
S129
T175
S178
S208
T210
S211
T213
T224
S225
S228
T249
S257
S298
S348
S354
S357
S378
S380
S384
T386
S406
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.