Protein: ENSP00000376765
Gene: PIAS3

LinkedOmicsKB © 2022-2023 Zhang Lab

PIAS3:
protein inhibitor of activated STAT 3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T84LLSLPPGTSPVGSPG222----------------9553
S89PGTSPVGSPGPLAPI6152--248--28-2915--54--20811-
T99PLAPIPPTLLAPGTL332--88----62--44------
Y423EVCPPPGYGLDGLQY866273-5451--18-613653497973--3513652
Y430YGLDGLQYSPVQGGD331--------116--54--41--
S431GLDGLQYSPVQGGDP410116---15129-----------427
S595PPPGRVSSIVAPGGA348------------4471--302
S616GPLPSGPSLTGCRSD17------------------7-
Showing 1 to 8 of 8 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T84LLSLPPGTSPVGSPG-----------
S89PGTSPVGSPGPLAPI-0.063-----0.063-----
T99PLAPIPPTLLAPGTL-----------
Y423EVCPPPGYGLDGLQY1.1e-10-0.09--0.881.5e-87.5e-9-0.26-
Y430YGLDGLQYSPVQGGD-----------
S431GLDGLQYSPVQGGDP-----------
S595PPPGRVSSIVAPGGA-----------
S616GPLPSGPSLTGCRSD-----------
Showing 1 to 8 of 8 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationCCRCCT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationCOADT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationGBMT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationHNSCCT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationLSCCT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationLUADT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationOVT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationPDACT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylationUCECT84S89T99Y423Y430S431S595S616proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.