INCENP: inner centromere protein
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2qfa chain C
4af3 chain D
5ieh chain C
5iek chain C
6gr8 chain B
6gr9 chain B
6yie chain C
6yie chain F
6yif chain C
6yih chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S72 RRKKRRIS YVQDENR 8 384 56 - - - - - 64 - 47 28 45 41 13 11 49 12 8 4 6 - Y73 RKKRRISY VQDENRD 1 9 9 - - - - - - - - - - - - - - - - - - - S91 RRLSRRKS RSSQLSS 2 100 - - - - - - - - 57 33 5 5 - - - - - - - - S93 LSRRKSRS SQLSSRR 1 33 - - - - - - - - - - - - - - 28 5 - - - - S119 TVVGENGS VLRRVTR 2 59 50 - - - - - - - - - - - - - 7 2 - - - - S142 TMALAAPS SPTPESP 5 95 7 - 8 8 - - - - 38 22 - - - - - - 2 1 - 9 S143 MALAAPSS PTPESPT 6 75 - - 4 4 - - 10 - 17 10 5 5 - - - - 2 1 12 5 T145 LAAPSSPT PESPTML 9 309 70 - 20 20 7 2 9 - 22 11 39 27 31 30 - - 8 4 - 9 S148 PSSPTPES PTMLTKK 9 343 67 - 12 12 26 28 18 - 15 10 39 35 5 4 - - 8 3 45 16 T195 STEPLPRT LSPTPAS 2 17 8 - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S72 RRKKRRIS YVQDENR 1e-15 - - - - 5.4e-3 2.5e-19 - 0.033 - - Y73 RKKRRISY VQDENRD - - - - - - - - - - - S91 RRLSRRKS RSSQLSS 1e-7 - - - - 1e-7 - - - - - S93 LSRRKSRS SQLSSRR - - - - - - - - - - - S119 TVVGENGS VLRRVTR - - - - - - - - - - - S142 TMALAAPS SPTPESP 0.41 - - - - 0.41 - - - - - S143 MALAAPSS PTPESPT - - - - - - - - - - - T145 LAAPSSPT PESPTML 6.2e-11 - -0.43 - - 0.4 3.3e-12 1.4e-9 - - - S148 PSSPTPES PTMLTKK 3.9e-3 - - 3.4e-3 - - 0.054 - - - 0.89 T195 STEPLPRT LSPTPAS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S72
Y73
S91
S93
S119
S142
S143
T145
S148
T195
S197
T199
T207
S208
T213
S214
S218
T219
T239
S253
S263
S269
S275
S291
T292
S300
S306
S311
S312
S314
S421
T424
S426
S446
S458
T478
S480
S481
S798
T802
S828
S831
T832
T844
T892
S893
S894
S899
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation CCRCC S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation COAD S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation GBM S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation HNSCC S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation LSCC S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation LUAD S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation OV S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation PDAC S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation UCEC S72 Y73 S91 S93 S119 S142 S143 T145 S148 T195 S197 T199 T207 S208 T213 S214 S218 T219 T239 S253 S263 S269 S275 S291 T292 S300 S306 S311 S312 S314 S421 T424 S426 S446 S458 T478 S480 S481 S798 T802 S828 S831 T832 T844 T892 S894 S899 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S72
Y73
S91
S93
S119
S142
S143
T145
S148
T195
S197
T199
T207
S208
T213
S214
S218
T219
T239
S253
S263
S269
S275
S291
T292
S300
S306
S311
S312
S314
S421
T424
S426
S446
S458
T478
S480
S481
S798
T802
S828
S831
T832
T844
T892
S893
S894
S899
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S72
Y73
S91
S93
S119
S142
S143
T145
S148
T195
S197
T199
T207
S208
T213
S214
S218
T219
T239
S253
S263
S269
S275
S291
T292
S300
S306
S311
S312
S314
S421
T424
S426
S446
S458
T478
S480
S481
S798
T802
S828
S831
T832
T844
T892
S893
S894
S899
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.