SPP1: secreted phosphoprotein 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3cxd chain P
3dsf chain P
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S24 IPVKQADS GSSEEKQ 6 185 9 - - - - - 9 - - - 74 64 5 3 - - 8 5 6 2 S26 VKQADSGS SEEKQLY 7 288 32 - 4 2 - - 90 - - - 19 17 49 40 - - 12 6 6 11 S27 KQADSGSS EEKQLYN 8 331 22 - 5 4 - - 54 - - - 34 29 49 43 39 10 19 7 5 11 S49 TWLNPDPS QKQNLLA 2 23 6 - - - - - - - - - 9 8 - - - - - - - - S62 LAPQNAVS SEETNDF 10 1254 122 - 103 80 6 3 99 - 76 48 108 92 105 89 69 16 97 40 83 18 S63 APQNAVSS EETNDFK 10 950 55 - 95 73 26 19 99 - 18 10 84 74 53 45 35 8 105 44 89 18 T66 NAVSSEET NDFKQET 6 157 13 - 31 28 - - 27 - - - - - 22 19 5 3 - - 7 2 T73 TNDFKQET LPSKSNE 5 81 8 - 12 4 - - - - - - 5 2 18 16 - - 11 5 - - S76 FKQETLPS KSNESHD 7 944 - - 103 79 - - 99 - 102 59 54 46 74 67 - - 105 44 94 18 S162 TYDGRGDS VVYGLRS 1 8 - - - - - - - - - - - - - - 7 1 - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S24 IPVKQADS GSSEEKQ 6.6e-10 - - - - - 6.6e-10 - - - - S26 VKQADSGS SEEKQLY 3.9e-11 - - - - - - 3.9e-11 - - - S27 KQADSGSS EEKQLYN 3.1e-13 - - - - - 3.0e-6 6.1e-13 0.45 - - S49 TWLNPDPS QKQNLLA - - - - - - - - - - - S62 LAPQNAVS SEETNDF 9.4e-21 - -5.4e-9 - - 7.6e-4 5e-24 1e-22 0.53 8.6e-7 0.088 S63 APQNAVSS EETNDFK 2e-13 - -1.1e-10 7.6e-3 - - 2.3e-17 1.4e-10 - 6e-10 0.48 T66 NAVSSEET NDFKQET 0.012 - -0.011 - - - - 1.1e-9 - - - T73 TNDFKQET LPSKSNE - - - - - - - - - - - S76 FKQETLPS KSNESHD 2.9e-30 - -1.6e-5 - - 1.3e-14 1.5e-11 1.4e-15 - 4.4e-11 0.001 S162 TYDGRGDS VVYGLRS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S24
S26
S27
S49
S62
S63
T66
T73
S76
S162
Y181
T185
T190
S191
S195
Y202
S215
S219
S224
Y225
T227
S228
S234
T237
S239
S243
S254
S258
S263
S267
S270
S275
S280
S291
S303
S308
S310
S311
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation CCRCC S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation COAD S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation GBM S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation HNSCC S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation LSCC S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation LUAD S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation OV S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation PDAC S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation UCEC S24 S26 S27 S49 S62 S63 T66 T73 S76 S162 Y181 T185 T190 S191 S195 Y202 S215 S219 S224 Y225 T227 S228 S234 T237 S239 S243 S254 S258 S263 S267 S270 S275 S280 S291 S303 S308 S310 S311 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S24
S26
S27
S49
S62
S63
T66
T73
S76
S162
Y181
T185
T190
S191
S195
Y202
S215
S219
S224
Y225
T227
S228
S234
T237
S239
S243
S254
S258
S263
S267
S270
S275
S280
S291
S303
S308
S310
S311
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S24
S26
S27
S49
S62
S63
T66
T73
S76
S162
Y181
T185
T190
S191
S195
Y202
S215
S219
S224
Y225
T227
S228
S234
T237
S239
S243
S254
S258
S263
S267
S270
S275
S280
S291
S303
S308
S310
S311
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.