Protein: ENSP00000379092
Gene: BTC

LinkedOmicsKB © 2022-2023 Zhang Lab

BTC:
betacellulin

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T166ETLGKDITPINEDIE6283--97----8047109108--19115716
Showing 1 to 1 of 1 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T166ETLGKDITPINEDIE-0.072-----2.2e-4----0.25
Showing 1 to 1 of 1 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: AndrogenT1661.4e-3----0.0560.0180.95-0.510.032
HALLMARK_ANDROGEN_RESPONSET1665.7e-3----0.230.140.35-0.340.11
xcell: Mast cellT1660.022-----0.450.0880.45-7.9e-30.44
HALLMARK_PANCREAS_BETA_CELLST1660.022----0.089-0.330.012-0.10.81
HALLMARK_WNT_BETA_CATENIN_SIGNALINGT1660.027----0.410.180.43-0.490.2
PROGENy: EstrogenT1660.038----0.0150.2-0.43-0.570.25
xcell: B cell memoryT1660.052----0.370.450.18--0.680.075
cibersort: MonocyteT1660.074----0.350.18-0.13-0.140.078
ARID1A mutationT1660.077----0.12----0.35
cibersort: NK cell activatedT1660.093-----0.810.210.021-0.770.88
Showing 1 to 10 of 258 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT166proteinRNASCNVmethylationCCRCCT166proteinRNASCNVmethylationCOADT166proteinRNASCNVmethylationGBMT166proteinRNASCNVmethylationHNSCCT166proteinRNASCNVmethylationLSCCT166proteinRNASCNVmethylationLUADT166proteinRNASCNVmethylationOVT166proteinRNASCNVmethylationPDACT166proteinRNASCNVmethylationUCECT166proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
MAP2K6T1661.1e-3----0.170.0440.028-0.590.26
LRRK1T1660.004----0.360.0312.7e-3---0.74
SCYL3T1665.9e-3----0.710.370.13-0.0440.17
ATMT1667.2e-3----0.0170.260.035--0.440.24
ERN2T1667.4e-3----0.22---0.0520.14
GRK6T1668.9e-3----0.120.20.25-0.340.35
INSRT1660.015----7.4e-3-0.58-0.68-0.220.013
ACVRL1T1660.02-----0.0960.1---
IRAK3T1660.023----0.840.350.15-0.990.013
STK36T1660.025---------0.025
Showing 1 to 10 of 538 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
SSU72T166-8.0e-4----0.39-0.86-8.2e-3--9.3e-4-0.025
BPGMT166-0.011-----0.0540.73-0.073--0.034-0.84
IMPA2T166-0.014-----0.065-0.79-0.61--0.82-8.9e-3
DUSP7T166-0.015-----0.41--0.25---0.025
PGAM1T166-0.018-----0.084-0.23-0.088--0.350.79
LPIN3T166-0.025-----0.008-0.19-0.26-0.7-0.74
VPS29T166-0.03-----8.5e-3-0.92-0.096--0.72-0.92
DUSP14T166-0.042-----1.5e-60.35---0.280.37
ACP1T166-0.053-----0.1-0.97-0.92--0.36-0.099
LPIN2T166-0.059-----0.1-0.81-0.018--0.80.78
Showing 1 to 10 of 240 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.