Protein: ENSP00000380252
Gene: NFE2L2

LinkedOmicsKB © 2022-2023 Zhang Lab

NFE2L2:
nuclear factor, erythroid 2 like 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S215VETTMVPSPEAKLTE865933-4930--9-784694868880--953814
S433PEKELPVSPGHRKTP759017-4736----985665588677--228164
Showing 1 to 2 of 2 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S215VETTMVPSPEAKLTE0.005-0.014---0.011.8e-60.58--0.29
S433PEKELPVSPGHRKTP7.8e-9-0.18---0.531.9e-107.7e-6---
Showing 1 to 2 of 2 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYS2152.1e-150.370.047--1.6e-36.6e-104.8e-7--0.029
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYS4339.7e-150.470.02--1.2e-56.2e-91.3e-5-0.890.006
HALLMARK_MTORC1_SIGNALINGS4331.1e-90.260.012--3.4e-68.9e-40.022-0.40.16
HALLMARK_XENOBIOTIC_METABOLISMS2153e-90.150.27--2.1e-52.3e-40.003--0.29
KEAP1 mutationS2151.3e-8-----9.6e-42.1e-6---
KINASE-PSP_CDK2S4333.4e-80.289.8e-4--1.8e-50.0730.13-0.0540.48
KINASE-PSP_CDK1S4334.4e-80.38.3e-3--6.4e-50.0350.012-0.0430.87
PERT-PSP_NOCODAZOLES4331.4e-70.833.1e-3--2.2e-50.175.8e-3-0.280.2
HALLMARK_MYC_TARGETS_V2S4331.0e-60.186.2e-4--1.2e-50.020.11-0.87-0.76
HALLMARK_XENOBIOTIC_METABOLISMS4331.4e-6-0.820.067--1.7e-62.6e-30.12--0.324.9e-3
Showing 1 to 10 of 516 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS215S433proteinRNASCNVmethylationCCRCCS215S433proteinRNASCNVmethylationCOADS215S433proteinRNASCNVmethylationGBMS215S433proteinRNASCNVmethylationHNSCCS215S433proteinRNASCNVmethylationLSCCS215S433proteinRNASCNVmethylationLUADS215S433proteinRNASCNVmethylationOVS215S433proteinRNASCNVmethylationPDACS215S433proteinRNASCNVmethylationUCECS215S433proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HDHD2S433-3.0e-6-0.14-0.1---4.5e-3-4.3e-5-0.46--0.0440.66
PTENS433-5.9e-6-0.82-0.079---1.4e-5-0.011-0.12--0.28-0.64
PALD1S433-2.1e-5-0.15-0.75---8.5e-5-0.29-0.015--0.92-0.051
PHPT1S433-9.3e-5-5.0e-4-0.23---0.04-6.5e-4-0.84--0.810.82
INPP5BS215-4.0e-40.64-0.12---0.17-1.0e-5-0.93---0.09
LHPPS433-4.3e-4-0.310.99---9.4e-3-0.1-0.01--0.120.96
PTENS215-8.5e-4-0.93-0.16---4.8e-3-4.2e-30.92---0.27
MDP1S433-9.8e-4-0.11-0.47---0.031-0.019-0.3---0.82
TNS2S433-0.001-0.37-0.028---0.072-0.12-0.2--0.6-0.66
INPP5JS433-1.7e-3-0.6-0.23----0.019-0.027---
Showing 1 to 10 of 480 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.