PRKAA1: protein kinase AMP-activated catalytic subunit alpha 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4red chain A
4red chain B
4rer chain A
4rew chain A
5ezv chain A
5ezv chain C
6c9f chain A
6c9g chain A
6c9h chain A
6c9j chain A
7jhg chain A
7jhh chain A
7jij chain A
7m74 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S356 KDFYLATS PPDSFLD 8 1010 22 - 103 80 42 39 99 - 108 62 88 82 81 72 - - 93 39 - - T382 VPFLVAET PRARHTL 7 464 45 - - - 72 63 46 - - - 63 59 13 12 46 12 - - 18 15 T388 ETPRARHT LDELNPQ 7 361 - - 32 23 - - 28 - 10 8 63 57 31 27 - - 45 18 19 - S397 DELNPQKS KHQGVRK 1 54 - - - - 26 28 - - - - - - - - - - - - - - S467 LQLYQVDS RTYLLDF 4 40 - - 8 7 - - - - - - 5 5 5 4 - - - - 6 - T469 LYQVDSRT YLLDFRS 1 11 - - - - - - - - - - - - - - - - - - 11 - Y470 YQVDSRTY LLDFRSI 1 11 - - - - - - - - - - - - - - - - - - 11 - S476 TYLLDFRS IDDEITE 1 11 - - - - - - - - - - - - - - - - - - 11 - S486 DEITEAKS GTATPQR 9 669 - - 9 8 70 73 35 - 37 22 35 33 56 51 68 16 68 25 54 9 T488 ITEAKSGT ATPQRSG 2 72 18 - - - 32 22 - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S356 KDFYLATS PPDSFLD -6.3e-12 - -0.58 -3.7e-4 - -0.061 -2.3e-5 -7.8e-8 - -0.21 - T382 VPFLVAET PRARHTL 2.1e-6 - - 2.3e-3 - - 4.9e-5 - 0.27 - - T388 ETPRARHT LDELNPQ 2.8e-3 - 0.016 - - - 0.076 1.7e-3 - -0.17 - S397 DELNPQKS KHQGVRK -0.032 - - -0.032 - - - - - - - S467 LQLYQVDS RTYLLDF - - - - - - - - - - - T469 LYQVDSRT YLLDFRS - - - - - - - - - - - Y470 YQVDSRTY LLDFRSI - - - - - - - - - - - S476 TYLLDFRS IDDEITE - - - - - - - - - - - S486 DEITEAKS GTATPQR -0.026 - - -0.25 - -0.073 -4.3e-4 -7.4e-7 0.95 3.9e-9 - T488 ITEAKSGT ATPQRSG 0.49 - - 0.49 - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S356
T382
T388
S397
S467
T469
Y470
S476
S486
T488
T490
S494
S496
Y500
S502
S506
S508
S516
S520
S524
T526
S527
S530
S531
T536
S541
T543
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation CCRCC S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation COAD S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation GBM S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation HNSCC S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation LSCC S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation LUAD S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation OV S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation PDAC S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation UCEC S356 T382 T388 S397 S467 T469 Y470 S476 S486 T488 T490 S494 S496 Y500 S502 S506 S508 S516 S520 S524 T526 S527 S530 S531 T536 S541 T543 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S356
T382
T388
S397
S467
T469
Y470
S476
S486
T488
T490
S494
S496
Y500
S502
S506
S508
S516
S520
S524
T526
S527
S530
S531
T536
S541
T543
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S356
T382
T388
S397
S467
T469
Y470
S476
S486
T488
T490
S494
S496
Y500
S502
S506
S508
S516
S520
S524
T526
S527
S530
S531
T536
S541
T543
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.