Protein: ENSP00000380785
Gene: HOOK2

LinkedOmicsKB © 2022-2023 Zhang Lab

HOOK2:
hook microtubule tethering protein 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S163KDTPDSLSPETYGNF963340-292745--5834595584782751898318
S172ETYGNFDSQSRRYYF14------------------4-
S181SRRYYFLSEEAEEGD320815---------54494644------
T230GRPEGEGTPGLTAKK845438-4433----4427444050442762812152
S316QLEATLTSCRRRLGE117------------------134
S442DPSLDPTSTPVDNLA110--------64----------
T443PSLDPTSTPVDNLAA82116-443825--739745--1046916
T613KARMVMQTMEPKQRP188-------------------
S630GAPPELHSLRTQLRE612624-1210------542220--41204
S689RAPAHAQSFLAQQRL169--3534----------------
Showing 1 to 10 of 13 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S163KDTPDSLSPETYGNF2.4e-7-0.91---1.2e-47.4e-41.2e-13--7.0e-6
S172ETYGNFDSQSRRYYF-----------
S181SRRYYFLSEEAEEGD-0.014------2.1e-60.2---
T230GRPEGEGTPGLTAKK4.8e-9--0.78--0.283.6e-122.9e-9--0.55-
S316QLEATLTSCRRRLGE-----------
S442DPSLDPTSTPVDNLA-----------
T443PSLDPTSTPVDNLAA-0.76---3.8e-5------2.2e-4
T613KARMVMQTMEPKQRP-----------
S630GAPPELHSLRTQLRE0.094------0.094---
S689RAPAHAQSFLAQQRL0.35-0.35--------
Showing 1 to 10 of 13 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationCCRCCS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationCOADS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationGBMS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationHNSCCS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationLSCCS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationLUADS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationOVS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationPDACS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylationUCECS163S172S181T230S316S442T443T613S630S689T698S700S710proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.