Protein: ENSP00000380942
Gene: ARHGEF12

LinkedOmicsKB © 2022-2023 Zhang Lab

ARHGEF12:
Rho guanine nucleotide exchange factor 12

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S22KKPIRHGSILNRESP101449105-103809710099-76441089910697761796398918
S28GSILNRESPTDKKQK715047-1716--9---981715--2172
S41QKVERIASHDFDPTD10107896-4929242190-8749646010193831985357815
S190GNMERITSPVLMGEE10124146-10380252944-10862103941101018319105446916
T267AQDGAVVTPSRPLGD239--------------5---313
S279LGDTLTVSEAETDPG475------9---151554225----
S296LGRTDCSSGDASRPS14------------------4-
S300DCSSGDASRPSSDNA726613-44--44---44414340--1986-
S303SGDASRPSSDNADSP91988-8819844-1995589--198174
S304GDASRPSSDNADSPK102549-88181882-19101099871104177
Showing 1 to 10 of 55 rows
102550100
rows per page

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S22KKPIRHGSILNRESP-0.14--0.034-3.7e-13-0.048-0.0122.2e-50.512.4e-8-1.9e-6
S28GSILNRESPTDKKQK-----------
S41QKVERIASHDFDPTD-1.2e-25--0.55-0.013--4e-11-3.2e-18-1.4e-11-0.110.11-8.0e-6
S190GNMERITSPVLMGEE-1.1e-20-5.9e-4-6.2e-6--1.8e-15-1.5e-14-2.9e-7-6.7e-5-3.9e-30.02
T267AQDGAVVTPSRPLGD-----------
S279LGDTLTVSEAETDPG-----------
S296LGRTDCSSGDASRPS-----------
S300DCSSGDASRPSSDNA-1.5e-14------1e-15-4.4e-3---
S303SGDASRPSSDNADSP-----------
S304GDASRPSSDNADSPK-----------
Showing 1 to 10 of 55 rows
102550100
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationCCRCCS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationCOADS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationGBMS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationHNSCCS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationLSCCS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationLUADS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationOVS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationPDACS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylationUCECS22S28S41S190T267S279S296S300S303S304S309S312T335S337S341T511S581S599S608S631T632S635S637S671S674T699T703T732T736S745S751S753T764S824S997S998T1148S1176S1196S1198S1200S1203S1288T1293S1308T1324Y1326S1327T1330S1331S1389S1394S1492S1541S1544proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.