TTC28: tetratricopeptide repeat domain 28
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S28 RRRREPES PPASAPI 10 1408 80 - 78 66 73 79 99 - 108 62 99 91 110 101 83 17 105 44 95 18 S32 EPESPPAS APIPLFG 4 92 - - 13 12 - - - - - - 5 5 20 20 15 2 - - - - T42 IPLFGADT IGQRSPD 2 16 - - 8 - - - 8 - - - - - - - - - - - - - S47 ADTIGQRS PDGPVLS 8 328 14 - 16 8 - - 44 - 7 3 29 25 36 32 20 6 - - 73 15 S1082 AKTVSYSS LGRTHHA 4 118 9 - - - - - 18 - - - - - 13 13 - - - - 49 16 S1316 YSRACASS ETESEAG 1 7 - - - - - - - - - - - - - - - - - - 5 2 S1320 CASSETES EAGDIMD 5 170 - - 4 3 - - 18 - - - 34 31 13 11 - - - - 49 7 S1339 EMNNKLNS VTDPTGF 1 12 - - - - - - - - - - - - - - - - - - 12 - S1359 RNNLFNRS CQSMTSL 3 66 - - - - - - 19 - - - 10 9 - - - - - - 26 2 T1370 MTSLFSNT VSPTQDG 3 38 - - 12 12 - - - - - - - - 4 4 - - 4 2 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S28 RRRREPES PPASAPI -1e-17 - 1.9e-7 -9.2e-9 - -2.6e-8 -2e-16 -7.5e-16 -0.13 -0.83 -0.91 S32 EPESPPAS APIPLFG -6.5e-8 - - - - - - -6.5e-8 - - - T42 IPLFGADT IGQRSPD - - - - - - - - - - - S47 ADTIGQRS PDGPVLS -2.4e-12 - - - - - -1.7e-3 -3.7e-7 - - -8.6e-5 S1082 AKTVSYSS LGRTHHA -0.03 - - - - - - - - - -0.03 S1316 YSRACASS ETESEAG - - - - - - - - - - - S1320 CASSETES EAGDIMD -0.023 - - - - - -0.023 - - - - S1339 EMNNKLNS VTDPTGF - - - - - - - - - - - S1359 RNNLFNRS CQSMTSL - - - - - - - - - - - T1370 MTSLFSNT VSPTQDG - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S28
S32
T42
S47
S1082
S1316
S1320
S1339
S1359
T1370
S1372
T1374
T1378
S1380
S1386
S1387
S1571
S1572
S1770
S2079
S2104
T2105
S2108
S2117
S2120
S2136
S2139
S2224
S2227
S2247
S2250
S2251
S2262
S2264
S2267
S2271
S2292
S2293
S2307
S2314
S2335
S2398
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation CCRCC S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation COAD S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation GBM S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation HNSCC S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation LSCC S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation LUAD S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation OV S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation PDAC S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation UCEC S28 S32 T42 S47 S1082 S1316 S1320 S1339 S1359 T1370 S1372 T1374 T1378 S1380 S1386 S1387 S1571 S1572 S1770 S2079 S2104 T2105 S2108 S2117 S2120 S2136 S2139 S2224 S2227 S2247 S2250 S2251 S2262 S2264 S2267 S2271 S2292 S2293 S2307 S2314 S2335 S2398 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S28
S32
T42
S47
S1082
S1316
S1320
S1339
S1359
T1370
S1372
T1374
T1378
S1380
S1386
S1387
S1571
S1572
S1770
S2079
S2104
T2105
S2108
S2117
S2120
S2136
S2139
S2224
S2227
S2247
S2250
S2251
S2262
S2264
S2267
S2271
S2292
S2293
S2307
S2314
S2335
S2398
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S28
S32
T42
S47
S1082
S1316
S1320
S1339
S1359
T1370
S1372
T1374
T1378
S1380
S1386
S1387
S1571
S1572
S1770
S2079
S2104
T2105
S2108
S2117
S2120
S2136
S2139
S2224
S2227
S2247
S2250
S2251
S2262
S2264
S2267
S2271
S2292
S2293
S2307
S2314
S2335
S2398
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.