USP34: ubiquitin specific peptidase 34
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
7w3r chain A
7w3r chain B
7w3u chain A
7w3u chain B
7w3u chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S139 CNLTEEES SKSSDPF 1 8 - - - - - - - - - - - - - - - - - - 5 3 S355 CNNESLVS DTETSIA 2 28 - - - - - - - - 11 7 5 5 - - - - - - - - S483 LAAKAQLS KQSSFAS 1 27 - - - - 15 12 - - - - - - - - - - - - - - S486 KAQLSKQS SFASLLN 2 16 7 - - - 4 5 - - - - - - - - - - - - - - S487 AQLSKQSS FASLLNT 10 1399 105 - 84 61 71 64 99 - 108 62 103 94 110 101 59 16 105 44 95 18 S490 SKQSSFAS LLNTNIP 7 147 22 - 12 12 21 15 - - - - 4 4 5 4 - - 22 12 12 2 S636 HGHNPPKS SCGTDLR 1 10 - - - - - - - - - - 5 5 - - - - - - - - T640 PPKSSCGT DLRNRKL 2 42 - - 17 16 - - - - - - 5 4 - - - - - - - - S681 DLVFNTES LPSVDNR 7 487 84 - 20 10 - - - - - - 69 63 45 40 34 9 11 7 77 18 S684 FNTESLPS VDNRMRM 1 7 - - - - - - - - - - - - - - - - - - 5 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S139 CNLTEEES SKSSDPF - - - - - - - - - - - S355 CNNESLVS DTETSIA - - - - - - - - - - - S483 LAAKAQLS KQSSFAS - - - - - - - - - - - S486 KAQLSKQS SFASLLN - - - - - - - - - - - S487 AQLSKQSS FASLLNT 7.6e-10 - -2.7e-5 -8.9e-5 - 2.3e-7 7.1e-33 9.6e-24 0.32 -1.3e-4 0.24 S490 SKQSSFAS LLNTNIP -6.3e-3 - - -0.14 - - - - - -0.017 - S636 HGHNPPKS SCGTDLR - - - - - - - - - - - T640 PPKSSCGT DLRNRKL - - - - - - - - - - - S681 DLVFNTES LPSVDNR -0.72 - 0.98 - - - -0.28 -0.57 - - 0.36 S684 FNTESLPS VDNRMRM - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S139
S355
S483
S486
S487
S490
S636
T640
S681
S684
T712
S1458
T1459
S1463
S1469
S1472
S1473
T1560
Y1721
S1751
S2401
S2488
T3350
S3358
S3359
T3364
S3367
T3381
T3383
S3384
T3385
S3386
T3400
S3406
S3410
S3411
S3439
Y3444
S3493
S3501
S3503
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation CCRCC S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation COAD S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation GBM S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation HNSCC S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation LSCC S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation LUAD S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation OV S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation PDAC S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation UCEC S139 S355 S483 S486 S487 S490 S636 T640 S681 S684 T712 S1458 T1459 S1463 S1469 S1472 S1473 T1560 Y1721 S1751 S2401 S2488 T3350 S3358 S3359 T3364 S3367 T3381 T3383 S3384 T3385 S3386 T3400 S3406 S3410 S3411 S3439 Y3444 S3493 S3501 S3503 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S139
S355
S483
S486
S487
S490
S636
T640
S681
S684
T712
S1458
T1459
S1463
S1469
S1472
S1473
T1560
Y1721
S1751
S2401
S2488
T3350
S3358
S3359
T3364
S3367
T3381
T3383
S3384
T3385
S3386
T3400
S3406
S3410
S3411
S3439
Y3444
S3493
S3501
S3503
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S139
S355
S483
S486
S487
S490
S636
T640
S681
S684
T712
S1458
T1459
S1463
S1469
S1472
S1473
T1560
Y1721
S1751
S2401
S2488
T3350
S3358
S3359
T3364
S3367
T3381
T3383
S3384
T3385
S3386
T3400
S3406
S3410
S3411
S3439
Y3444
S3493
S3501
S3503
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.