DOT1L: DOT1 like histone lysine methyltransferase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1nw3 chain A
2mv7 chain B
3qow chain A
3qox chain A
3sr4 chain A
3sx0 chain A
3uwp chain A
4ek9 chain A
4ekg chain A
4eki chain A
4eqz chain A
4er0 chain A
4er3 chain A
4er5 chain A
4er6 chain A
4er7 chain A
4hra chain A
4wvl chain A
5drt chain A
5drt chain B
5dry chain A
5dry chain B
5dsx chain A
5dsx chain B
5dt2 chain A
5dt2 chain B
5dtm chain A
5dtm chain B
5dtq chain A
5dtq chain B
5dtr chain A
5dtr chain B
5juw chain A
5mvs chain A
5mvs chain B
5mw3 chain A
5mw3 chain B
5mw4 chain A
5mw4 chain B
6in3 chain A
6j99 chain K
6jm9 chain X
6jma chain X
6jn2 chain B
6nj9 chain K
6nj9 chain M
6nn6 chain K
6nog chain K
6nqa chain K
6o96 chain K
6te6 chain A
6te6 chain B
6tel chain A
6tel chain B
6ten chain A
6ten chain B
7bwd chain K
7edp chain B
7xcr chain K
7xct chain K
7xct chain M
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S297 IMRVVELS PLKGSVS 6 202 54 - 16 16 - - - - 16 11 30 27 - - - - 9 3 20 - S351 RQQRESKS NAATPTK 2 81 52 - - - - - - - - - 15 14 - - - - - - - - T355 ESKSNAAT PTKGPEG 6 319 55 - - - 58 41 10 - - - 20 19 48 44 20 4 - - - - S374 PADAPMDS GAEEEKA 10 1012 87 - 48 37 50 48 81 - 73 43 103 95 70 65 25 7 65 27 70 18 T385 EEKAGAAT VKKPSPS 1 39 - - - - - - - - - - - - - - - - 26 13 - - S442 ALHAQTVS QTAASSP 1 3 - - - - - - - - - - - - - - - - 2 1 - - T444 HAQTVSQT AASSPQD 3 29 - - 7 7 - - - - - - - - 5 4 - - 5 1 - - S447 TVSQTAAS SPQDAYR 1 6 - - - - - - - - - - - - - - - - - - 6 - S448 VSQTAASS PQDAYRS 5 109 - - - - 10 16 18 - 22 14 - - 13 11 - - 3 2 - - S458 DAYRSPHS PFYQLPP 3 41 6 - - - - - - - - - - - - - 14 3 - - 7 11
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S297 IMRVVELS PLKGSVS 6.5e-15 - - - - - 6.4e-15 - - - - S351 RQQRESKS NAATPTK - - - - - - - - - - - T355 ESKSNAAT PTKGPEG 5.9e-35 - - 9.8e-12 - - 2.9e-11 2.7e-15 - - - S374 PADAPMDS GAEEEKA 4.2e-24 - 4.3e-4 0.004 - 3.4e-6 1.3e-28 1.9e-7 - -0.01 0.045 T385 EEKAGAAT VKKPSPS -0.014 - - - - - - - - -0.014 - S442 ALHAQTVS QTAASSP - - - - - - - - - - - T444 HAQTVSQT AASSPQD - - - - - - - - - - - S447 TVSQTAAS SPQDAYR - - - - - - - - - - - S448 VSQTAASS PQDAYRS -0.24 - - - - -0.24 - - - - - S458 DAYRSPHS PFYQLPP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S297
S351
T355
S374
T385
S442
T444
S447
S448
S458
S471
S741
Y771
T772
S775
S786
S822
S826
S834
S899
T900
S902
T984
S1001
S1007
S1008
S1009
S1032
S1035
S1055
S1061
S1062
S1065
S1104
S1153
S1213
S1246
S1259
T1274
S1349
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation CCRCC S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation COAD S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation GBM S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation HNSCC S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation LSCC S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation LUAD S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation OV S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation PDAC S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation UCEC S297 S351 T355 S374 T385 S442 T444 S447 S448 S458 S471 S741 Y771 T772 S775 S786 S822 S826 S834 S899 T900 S902 T984 S1001 S1007 S1008 S1009 S1032 S1035 S1055 S1061 S1062 S1065 S1104 S1153 S1213 S1246 S1259 T1274 S1349 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S297
S351
T355
S374
T385
S442
T444
S447
S448
S458
S471
S741
Y771
T772
S775
S786
S822
S826
S834
S899
T900
S902
T984
S1001
S1007
S1008
S1009
S1032
S1035
S1055
S1061
S1062
S1065
S1104
S1153
S1213
S1246
S1259
T1274
S1349
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S297
S351
T355
S374
T385
S442
T444
S447
S448
S458
S471
S741
Y771
T772
S775
S786
S822
S826
S834
S899
T900
S902
T984
S1001
S1007
S1008
S1009
S1032
S1035
S1055
S1061
S1062
S1065
S1104
S1153
S1213
S1246
S1259
T1274
S1349
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.