JMJD1C: jumonji domain containing 1C
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ypd chain A
2ypd chain B
5fzo chain A
5fzo chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S284 YTRAQANS PRPAMNS 10 466 48 - 9 8 4 5 18 - 6 4 35 31 44 40 28 7 60 27 74 18 S317 RPNKRKGS DSSIPDE 9 516 40 - - - 76 67 98 - 13 5 5 4 21 19 27 7 39 16 63 16 S319 NKRKGSDS SIPDEEK 7 666 88 - 103 80 25 20 - - 72 37 25 22 70 65 - - 38 21 - - S320 KRKGSDSS IPDEEKM 10 898 113 - 103 80 10 8 64 - 77 41 59 54 83 77 20 5 51 25 23 5 S373 RLRTDNVS DFSESSD 6 106 - - - - - - 28 - 6 3 5 4 18 16 - - 3 2 17 4 S376 TDNVSDFS ESSDSEN 7 116 7 - - - - - 9 - 5 4 20 19 10 8 - - 4 1 25 4 S378 NVSDFSES SDSENSN 8 259 53 - 4 4 34 37 - - 6 3 5 5 24 20 - - 17 6 34 7 S379 VSDFSESS DSENSNK 10 576 9 - 24 23 61 64 28 - 65 36 15 14 14 11 52 13 63 26 53 5 S501 LPKEKFVS RPPTPKC 4 127 - - - - - - 27 - 12 6 - - - - - - 33 16 30 3 T505 KFVSRPPT PKCVIDI 10 1401 114 - 87 66 85 94 99 - 102 58 103 94 82 77 77 17 98 41 89 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S284 YTRAQANS PRPAMNS 0.28 - - - - - 9.2e-3 8.6e-10 - -0.046 -4.4e-6 S317 RPNKRKGS DSSIPDE 9.7e-7 - - 2e-15 - - - 1.8e-3 - -0.002 0.068 S319 NKRKGSDS SIPDEEK 3.4e-14 - 0.31 2.7e-8 - 4.1e-6 0.082 2.3e-8 - 0.96 - S320 KRKGSDSS IPDEEKM 2e-11 - 0.31 - - 9e-7 0.016 1.5e-10 - 0.81 - S373 RLRTDNVS DFSESSD - - - - - - - - - - - S376 TDNVSDFS ESSDSEN 2.9e-3 - - - - - 2.9e-3 - - - - S378 NVSDFSES SDSENSN 9e-14 - - 8.6e-13 - - - 6.9e-4 - - - S379 VSDFSESS DSENSNK 1.4e-12 - -0.92 1.1e-14 - 8.4e-10 - - 8.6e-5 -0.064 - S501 LPKEKFVS RPPTPKC -0.53 - - - - - - - - -0.53 - T505 KFVSRPPT PKCVIDI 6.6e-17 - 0.24 1.8e-28 - 4.1e-13 0.026 6.0e-4 8.9e-5 -5.5e-3 -7.4e-3
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S284
S317
S319
S320
S373
S376
S378
S379
S501
T505
S601
S617
S638
S639
S641
S652
S701
S943
S984
S1029
S1058
S1185
S1228
T1231
T1233
S1559
S1748
T1978
S1982
S1988
S1989
S1992
S2005
S2007
T2031
S2047
T2052
S2053
S2057
S2081
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation CCRCC S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation COAD S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation GBM S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation HNSCC S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation LSCC S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation LUAD S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation OV S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation PDAC S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation UCEC S284 S317 S319 S320 S373 S376 S378 S379 S501 T505 S601 S617 S638 S639 S641 S652 S701 S943 S984 S1029 S1058 S1185 S1228 T1231 T1233 S1559 S1748 T1978 S1982 S1988 S1989 S1992 S2005 S2007 T2031 S2047 T2052 S2053 S2057 S2081 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S284
S317
S319
S320
S373
S376
S378
S379
S501
T505
S601
S617
S638
S639
S641
S652
S701
S943
S984
S1029
S1058
S1185
S1228
T1231
T1233
S1559
S1748
T1978
S1982
S1988
S1989
S1992
S2005
S2007
T2031
S2047
T2052
S2053
S2057
S2081
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S284
S317
S319
S320
S373
S376
S378
S379
S501
T505
S601
S617
S638
S639
S641
S652
S701
S943
S984
S1029
S1058
S1185
S1228
T1231
T1233
S1559
S1748
T1978
S1982
S1988
S1989
S1992
S2005
S2007
T2031
S2047
T2052
S2053
S2057
S2081
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.