Protein: ENSP00000382423
Gene: MAP3K1

LinkedOmicsKB © 2022-2023 Zhang Lab

MAP3K1:
mitogen-activated protein kinase kinase kinase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S21FPGARATSPEAGGGG101307115-9572687544-9352103951101014810101426518
S35GGALKASSAPAAAAG715423-86----6320192523--5214-
S137APDSGASSPAAAEPG19------------------72
S154RAPAAEPSPAAAPAG18--------------71----
S250PASKGRRSPSPGNSP1063771-29274527-734163585954381050244-
S252SKGRRSPSPGNSPSG941739---232253-2214252216156616241446-
S256RSPSPGNSPSGRTVK39128---------98----3313--
S266GRTVKSESPGVRRKR10119171-907116119-1015910899101928219105449518
S275GVRRKRVSPVPFQSG91082122-5435--97-4527108999889831966279518
S281VSPVPFQSGRITPPR731238-3635--46-332054----3216407
Showing 1 to 10 of 25 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S21FPGARATSPEAGGGG1.3e-25-2.4e-61.4e-5-0.128.3e-35.9e-18-0.421.2e-85.6e-3
S35GGALKASSAPAAAAG5.1e-5-----0.0216.3e-4---
S137APDSGASSPAAAEPG-----------
S154RAPAAEPSPAAAPAG-----------
S250PASKGRRSPSPGNSP1.8e-7--0.3--3.2e-59.6e-77.4e-60.13-0.21-
S252SKGRRSPSPGNSPSG-0.83--0.15--0.620.03-0.49-1.7e-5-
S256RSPSPGNSPSGRTVK0.98--------0.98-
S266GRTVKSESPGVRRKR1.3e-7-1.1e-4--0.520.45.5e-71.8e-6-4.5e-53.7e-3
S275GVRRKRVSPVPFQSG0.6--9.1e-3--0.21-2.3e-30.110.12-0.435.8e-4
S281VSPVPFQSGRITPPR-0.12-2.8e-4---0.076----4.6e-6-
Showing 1 to 10 of 25 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationCCRCCS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationCOADS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationGBMS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationHNSCCS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationLSCCS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationLUADS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationOVS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationPDACS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylationUCECS21S35S137S154S250S252S256S266S275S281T285S292S506S507S531S921S923S1018S1026S1043T1111T1114S1157T1400S1455proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.