DLG4: discs large MAGUK scaffold protein 4
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1kef chain A
2mes chain B
3i4w chain A
3i4w chain B
3i4w chain C
3i4w chain D
3k82 chain A
3zrt chain A
3zrt chain B
3zrt chain C
3zrt chain D
5j7j chain B
5jxb chain A
5jxb chain C
6qjd chain A
6qjd chain B
6qjd chain C
6qjd chain D
6qjf chain A
6qjf chain B
6qjf chain C
6qjf chain D
6qjg chain A
6qjg chain B
6qjg chain C
6qjg chain D
6qji chain A
6qji chain B
6qji chain C
6qji chain D
6qji chain E
6qji chain F
6qjj chain A
6qjk chain A
6qjl chain A
6qjl chain B
6qjn chain A
6qjn chain B
6spv chain A
6spz chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S73 ITLERGNS GLGFSIA 1 53 - - - - - - 53 - - - - - - - - - - - - - S217 DKILAVNS VGLEDVM 1 36 - - - - - - 36 - - - - - - - - - - - - - Y240 KNTYDVVY LKVAKPS 1 98 - - - - - - 98 - - - - - - - - - - - - - S295 PTSPRRYS PVAKDLL 9 1132 113 - 90 76 39 41 99 - 56 32 83 76 92 84 - - 97 41 95 18 T387 KNAGQTVT IIAQYKP 2 19 - - - - - - - - - - 5 5 5 4 - - - - - - Y392 TVTIIAQY KPEEYSR 2 19 - - - - - - - - - - 5 5 5 4 - - - - - - S414 LREQLMNS SLGSGTA 1 37 - - - - - - 37 - - - - - - - - - - - - - S415 REQLMNSS LGSGTAS 1 99 - - - - - - 99 - - - - - - - - - - - - - S418 LMNSSLGS GTASLRS 1 99 - - - - - - 99 - - - - - - - - - - - - - S422 SLGSGTAS LRSNPKR 2 98 - - - - - - 90 - - - - - - - - - 6 2 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S73 ITLERGNS GLGFSIA - - - - - - - - - - - S217 DKILAVNS VGLEDVM - - - - - - - - - - - Y240 KNTYDVVY LKVAKPS - - - - - - - - - - - S295 PTSPRRYS PVAKDLL -1.8e-32 - -0.017 -2e-12 - -1.4e-3 -3.5e-16 -3.6e-18 - 2.4e-4 -2.3e-8 T387 KNAGQTVT IIAQYKP - - - - - - - - - - - Y392 TVTIIAQY KPEEYSR - - - - - - - - - - - S414 LREQLMNS SLGSGTA - - - - - - - - - - - S415 REQLMNSS LGSGTAS - - - - - - - - - - - S418 LMNSSLGS GTASLRS - - - - - - - - - - - S422 SLGSGTAS LRSNPKR - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S73
S217
Y240
S295
T387
Y392
S414
S415
S418
S422
S425
S449
S453
S466
S478
S480
T482
S509
S511
S513
S519
S584
S606
S654
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation CCRCC S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation COAD S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation GBM S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation HNSCC S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation LSCC S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation LUAD S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation OV S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation PDAC S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation UCEC S73 S217 Y240 S295 T387 Y392 S414 S415 S418 S422 S425 S449 S453 S466 S478 S480 T482 S509 S511 S513 S519 S584 S606 S654 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S73
S217
Y240
S295
T387
Y392
S414
S415
S418
S422
S425
S449
S453
S466
S478
S480
T482
S509
S511
S513
S519
S584
S606
S654
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S73
S217
Y240
S295
T387
Y392
S414
S415
S418
S422
S425
S449
S453
S466
S478
S480
T482
S509
S511
S513
S519
S584
S606
S654
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.