ROCK1: Rho associated coiled-coil containing protein kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1s1c chain X
1s1c chain Y
2esm chain A
2esm chain B
2etk chain A
2etk chain B
2etr chain A
2etr chain B
2v55 chain A
2v55 chain C
3d9v chain A
3d9v chain B
3ncz chain A
3ncz chain B
3ncz chain C
3ncz chain D
3ndm chain A
3ndm chain B
3ndm chain C
3ndm chain D
3o0z chain A
3o0z chain B
3o0z chain C
3o0z chain D
3tv7 chain A
3tv7 chain B
3tv7 chain C
3tv7 chain D
3twj chain A
3twj chain B
3twj chain C
3twj chain D
3v8s chain A
3v8s chain B
3v8s chain C
3v8s chain D
4l2w chain A
4l2w chain B
4l2w chain C
4l2w chain D
4w7p chain A
4w7p chain B
4w7p chain C
4w7p chain D
4yvc chain A
4yvc chain B
4yve chain A
4yve chain B
5bml chain A
5bml chain B
5f5p chain C
5f5p chain D
5f5p chain E
5f5p chain F
5hvu chain A
5hvu chain B
5kks chain A
5kks chain B
5kkt chain A
5kkt chain B
5uzj chain A
5uzj chain B
5wne chain A
5wne chain B
5wne chain C
5wne chain D
5wnf chain A
5wnf chain B
5wnf chain C
5wnf chain D
5wng chain A
5wng chain B
5wng chain C
5wng chain D
5wnh chain A
5wnh chain B
5wnh chain C
5wnh chain D
6e9w chain A
6e9w chain B
7jou chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T416 ANPNDNRT SSNADKS 7 309 14 - 85 64 - - - - 6 3 29 28 30 28 - - 10 3 - 9 S417 NPNDNRTS SNADKSL 4 112 - - - - - - - - - - - - 5 4 22 4 36 15 22 4 S567 TAVRLRKS HTEMSKS 2 26 - - - - - - 18 - - - 4 4 - - - - - - - - S574 SHTEMSKS ISQLESL 1 9 - - - - - - 9 - - - - - - - - - - - - - S576 TEMSKSIS QLESLNR 3 53 - - - - - - 18 - - - 15 15 - - - - 3 2 - - S704 RLTDKHQS IEEAKSV 5 219 - - 4 4 - - 90 - - - 44 40 8 7 - - - - 18 4 S742 VQIEKQCS MLDVDLK 1 9 - - - - - - 9 - - - - - - - - - - - - - T1024 IDRKKANT QDLRKKE 6 404 - - 74 54 5 4 - - - - 58 55 48 45 - - 9 4 37 11 S1098 RAKLLDLS DSTSVAS 7 166 37 - - - 4 5 - - 22 13 10 9 12 12 - - 7 3 19 13 T1101 LLDLSDST SVASFPS 3 24 - - - - 4 5 - - - - - - 5 4 - - - - 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T416 ANPNDNRT SSNADKS -1.1e-21 - -4.8e-10 - - - -3.9e-8 -1.3e-6 - - - S417 NPNDNRTS SNADKSL 0.18 - - - - - - - - 0.18 - S567 TAVRLRKS HTEMSKS - - - - - - - - - - - S574 SHTEMSKS ISQLESL - - - - - - - - - - - S576 TEMSKSIS QLESLNR - - - - - - - - - - - S704 RLTDKHQS IEEAKSV -1.9e-10 - - - - - -1.9e-10 - - - - S742 VQIEKQCS MLDVDLK - - - - - - - - - - - T1024 IDRKKANT QDLRKKE -0.99 - 3.5e-4 - - - -2.9e-9 -0.5 - - 2.6e-3 S1098 RAKLLDLS DSTSVAS -0.12 - - - - -0.12 - - - - - T1101 LLDLSDST SVASFPS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T416
S417
S567
S574
S576
S704
S742
T1024
S1098
T1101
S1102
S1105
S1108
S1146
S1147
S1162
S1165
T1180
Y1185
T1189
S1328
S1333
T1334
S1336
T1337
S1341
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation CCRCC T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation COAD T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation GBM T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation HNSCC T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation LSCC T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation LUAD T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation OV T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation PDAC T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation UCEC T416 S417 S567 S574 S576 S704 S742 T1024 S1098 T1101 S1102 S1105 S1108 S1146 S1147 S1162 S1165 T1180 Y1185 T1189 S1328 S1333 T1334 S1336 T1337 S1341 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T416
S417
S567
S574
S576
S704
S742
T1024
S1098
T1101
S1102
S1105
S1108
S1146
S1147
S1162
S1165
T1180
Y1185
T1189
S1328
S1333
T1334
S1336
T1337
S1341
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T416
S417
S567
S574
S576
S704
S742
T1024
S1098
T1101
S1102
S1105
S1108
S1146
S1147
S1162
S1165
T1180
Y1185
T1189
S1328
S1333
T1334
S1336
T1337
S1341
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.