Protein: ENSP00000383053
Gene: EPHB2

LinkedOmicsKB © 2022-2023 Zhang Lab

EPHB2:
EPH receptor B2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S575RGFERADSEYTDKLQ8510----928791-28171088822472292311
T585TDKLQHYTSGHMTPG118------18-------------
S586DKLQHYTSGHMTPGM2105------54-3417----------
S776RFLEDDTSDPTYTSA10119345-41399710099-975784737971541397408918
Y780DDTSDPTYTSALGGK171----3239--------------
S898KAMAPLSSGINLPLL8525----848673-1271512322617272324213
Y912LDRTIPDYTSFNTVD217----458-------------
Showing 1 to 7 of 7 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S575RGFERADSEYTDKLQ4.0e-4--2.2e-9-2.9e-5----0.35-0.031
T585TDKLQHYTSGHMTPG-----------
S586DKLQHYTSGHMTPGM2.8e-3----2.8e-3-----
S776RFLEDDTSDPTYTSA4.3e-15--9.3e-94.4e-5-6.7e-73.4e-196.9e-146.5e-30.064-0.033
Y780DDTSDPTYTSALGGK0.79--0.79-------
S898KAMAPLSSGINLPLL-9.8e-4---1.6e-3---0.6--1.3e-4-0.9
Y912LDRTIPDYTSFNTVD-----------
Showing 1 to 7 of 7 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS575T585S586S776Y780S898Y912proteinRNASCNVmethylationCCRCCS575T585S586S776Y780S898Y912proteinRNASCNVmethylationCOADS575T585S586S776Y780S898Y912proteinRNASCNVmethylationGBMS575T585S586S776Y780S898Y912proteinRNASCNVmethylationHNSCCS575T585S586S776Y780S898Y912proteinRNASCNVmethylationLSCCS575T585S586S776Y780S898Y912proteinRNASCNVmethylationLUADS575T585S586S776Y780S898Y912proteinRNASCNVmethylationOVS575T585S586S776Y780S898Y912proteinRNASCNVmethylationPDACS575T585S586S776Y780S898Y912proteinRNASCNVmethylationUCECS575T585S586S776Y780S898Y912proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.