NEDD4L: NEDD4 like E3 ubiquitin protein ligase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2laj chain A
2lb2 chain A
2lty chain A
2mpt chain A
2mpt chain B
2nsq chain A
2oni chain A
3jvz chain C
3jvz chain D
3jw0 chain C
3jw0 chain D
5hpk chain A
6zbt chain E
6zbt chain F
6zbt chain G
6zbt chain H
6zc9 chain E
6zc9 chain F
6zc9 chain G
6zc9 chain H
7lp1 chain A
7lp2 chain A
7lp2 chain C
7lp2 chain E
7lp3 chain A
7lp3 chain C
7lp4 chain A
7lp5 chain A
7nmz chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S28 ILRVKVVS GIDLAKK 1 6 - - - - - - - - - - - - - - - - - - 6 - S179 HGWEVVDS NDSASQH 1 18 - - - - - - - - 11 7 - - - - - - - - - - S182 EVVDSNDS ASQHQEE 1 18 - - - - - - - - 11 7 - - - - - - - - - - S184 VDSNDSAS QHQEELP 1 18 - - - - - - - - 11 7 - - - - - - - - - - T219 VNHNNRTT QWHRPSL 2 45 - - - - - - 37 - - - - - - - - - - - 5 3 S225 TTQWHRPS LMDVSSE 5 252 - - 52 33 - - 54 - 19 8 19 18 26 23 - - - - - - S231 PSLMDVSS ESDNNIR 1 6 - - 4 2 - - - - - - - - - - - - - - - - S233 LMDVSSES DNNIRQI 5 108 - - 9 8 - - 46 - 7 3 - - 4 4 - - 18 9 - - S256 FRSRRHIS EDLEPEP 1 54 - - 33 21 - - - - - - - - - - - - - - - - S297 ALPPPPAS PGSRTSP 4 148 - - 39 31 - - 9 - 23 13 - - 18 15 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S28 ILRVKVVS GIDLAKK - - - - - - - - - - - S179 HGWEVVDS NDSASQH - - - - - - - - - - - S182 EVVDSNDS ASQHQEE - - - - - - - - - - - S184 VDSNDSAS QHQEELP - - - - - - - - - - - T219 VNHNNRTT QWHRPSL - - - - - - - - - - - S225 TTQWHRPS LMDVSSE 2.8e-8 - 4.7e-9 - - - - 0.046 - - - S231 PSLMDVSS ESDNNIR - - - - - - - - - - - S233 LMDVSSES DNNIRQI - - - - - - - - - - - S256 FRSRRHIS EDLEPEP 0.046 - 0.046 - - - - - - - - S297 ALPPPPAS PGSRTSP 0.49 - 0.8 - - 0.47 - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S28
S179
S182
S184
T219
S225
S231
S233
S256
S297
T302
S303
S312
T318
S321
S327
S328
S335
S340
S342
T344
T367
T369
T383
T384
T412
S432
S446
S448
S449
T451
T453
S455
S464
S475
S479
S483
Y485
S487
S541
S631
S932
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation CCRCC S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation COAD S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation GBM S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation HNSCC S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation LSCC S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation LUAD S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation OV S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation PDAC S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation UCEC S28 S179 S182 S184 T219 S225 S231 S233 S256 S297 T302 S303 S312 T318 S321 S327 S328 S335 S340 S342 T344 T367 T369 T383 T384 T412 S432 S446 S448 S449 T451 T453 S455 S464 S475 S479 S483 Y485 S487 S541 S631 S932 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S28
S179
S182
S184
T219
S225
S231
S233
S256
S297
T302
S303
S312
T318
S321
S327
S328
S335
S340
S342
T344
T367
T369
T383
T384
T412
S432
S446
S448
S449
T451
T453
S455
S464
S475
S479
S483
Y485
S487
S541
S631
S932
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S28
S179
S182
S184
T219
S225
S231
S233
S256
S297
T302
S303
S312
T318
S321
S327
S328
S335
S340
S342
T344
T367
T369
T383
T384
T412
S432
S446
S448
S449
T451
T453
S455
S464
S475
S479
S483
Y485
S487
S541
S631
S932
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.