- WDR43:
- WD repeat domain 43
Lollipop plot
Phosphosites location and occurrence
Structure
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Site
| Sequence | Cohorts | Total | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N |
S77 | ARLQAKESPQRKKRK | 10 | 1535 | 122 | - | 103 | 80 | 97 | 100 | 99 | - | 108 | 62 | 108 | 99 | 105 | 97 | 76 | 17 | 105 | 44 | 95 | 18 |
S122 | ELHSKLISGGHDNRV | 1 | 8 | 8 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
T321 | NCTIQIATPGKGKKS | 2 | 15 | 7 | - | 4 | 4 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
T394 | TAITKVRTPVMNSEA | 9 | 1101 | 71 | - | 91 | 76 | 29 | 24 | - | - | 108 | 62 | 73 | 68 | 106 | 98 | 62 | 15 | 87 | 35 | 87 | 9 |
S431 | QVESKRKSGGNEVSI | 10 | 500 | 78 | - | 4 | 4 | 47 | 34 | 18 | - | 23 | 14 | 89 | 81 | 27 | 24 | 12 | 5 | 11 | 6 | 19 | 4 |
S437 | KSGGNEVSIEERLGA | 2 | 40 | - | - | - | - | - | - | - | - | - | - | - | - | 17 | 16 | - | - | - | - | 5 | 2 |
S590 | EKTKGATSPGQKAKL | 7 | 303 | - | - | - | - | - | - | 81 | - | 4 | 4 | 30 | 27 | 15 | 12 | 12 | 4 | 5 | 2 | 89 | 18 |
S603 | KLVYEEESSEEESDD | 1 | 12 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 12 | - |
S604 | LVYEEESSEEESDDE | 1 | 12 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 12 | - |
S608 | EESSEEESDDEIADK | 1 | 12 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 12 | - |
Tumor and normal comparison
Site
| Sequence | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
---|---|---|---|---|---|---|---|---|---|---|---|---|
S77 | ARLQAKESPQRKKRK | 7.4e-98 | - | 3.8e-16 | 9.8e-32 | - | 4.7e-23 | 5.7e-35 | 5.5e-33 | 1.7e-3 | 0.26 | 0.29 |
S122 | ELHSKLISGGHDNRV | - | - | - | - | - | - | - | - | - | - | - |
T321 | NCTIQIATPGKGKKS | - | - | - | - | - | - | - | - | - | - | - |
T394 | TAITKVRTPVMNSEA | 3.8e-23 | - | 6.5e-6 | 1.8e-5 | - | 9.9e-4 | 1.3e-14 | 8.5e-17 | 0.027 | -4.1e-5 | - |
S431 | QVESKRKSGGNEVSI | 7.5e-39 | - | - | 6.7e-17 | - | 0.024 | 9.9e-28 | 5.4e-6 | - | - | - |
S437 | KSGGNEVSIEERLGA | - | - | - | - | - | - | - | - | - | - | - |
S590 | EKTKGATSPGQKAKL | -0.63 | - | - | - | - | - | 1.8e-3 | - | - | - | -1.4e-4 |
S603 | KLVYEEESSEEESDD | - | - | - | - | - | - | - | - | - | - | - |
S604 | LVYEEESSEEESDDE | - | - | - | - | - | - | - | - | - | - | - |
S608 | EESSEEESDDEIADK | - | - | - | - | - | - | - | - | - | - | - |
Phenotype and mutation association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
HALLMARK_MYC_TARGETS_V2 | S77 | 1.9e-79 | 9.1e-6 | 6.3e-4 | 6.3e-7 | 1.2e-6 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 5.1e-5 | 3.4e-7 | 2.2e-16 |
HALLMARK_E2F_TARGETS | S77 | 1.9e-74 | 2.2e-5 | 1.0e-6 | 4.3e-6 | 3.5e-6 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 0.094 | 1.2e-6 | 2.2e-16 |
HALLMARK_G2M_CHECKPOINT | S77 | 4.2e-69 | 6.0e-5 | 6.7e-8 | 6.3e-5 | 6.3e-6 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 0.32 | 8.1e-7 | 1.4e-12 |
HALLMARK_DNA_REPAIR | S77 | 7.5e-50 | 1.9e-3 | 3.3e-3 | 4.8e-3 | 2.6e-6 | 3e-10 | 2.2e-16 | 2.4e-5 | 1.4e-4 | 3.1e-8 | 1.1e-7 |
HALLMARK_MYC_TARGETS_V1 | S77 | 2.2e-42 | 3.1e-4 | 0.003 | 0.008 | 2.4e-4 | 1.6e-6 | 2.2e-16 | 2.4e-9 | 0.01 | 9.7e-3 | 9.6e-10 |
PERT-PSP_NOCODAZOLE | T394 | 7e-39 | 4.9e-6 | 3.0e-6 | 0.93 | - | 3.5e-8 | 2.7e-5 | 2.2e-16 | -0.52 | 1.6e-5 | 2.2e-16 |
xcell: T cell CD4+ Th1 | S77 | 3.7e-37 | 5.3e-4 | -0.78 | 2.7e-5 | 2.0e-4 | 6e-8 | 1.6e-9 | 1.4e-11 | 0.3 | 5.1e-4 | 1e-10 |
KINASE-PSP_CDK1 | S77 | 2.2e-34 | 1.5e-3 | 0.29 | 4.3e-3 | 3.6e-8 | 1.4e-9 | 2.2e-9 | 2.1e-8 | 0.017 | 1.4e-3 | 4.2e-3 |
KINASE-PSP_CDK2 | S77 | 2.2e-34 | 3.2e-4 | 0.041 | 8.6e-5 | 2.7e-5 | 2.2e-16 | 3.2e-4 | 7.5e-7 | 0.12 | 0.01 | 5.7e-5 |
KINASE-PSP_CDK2 | T394 | 4.7e-34 | 9.8e-5 | 1.3e-5 | 0.56 | - | 6.7e-8 | 3.2e-7 | 2.2e-16 | -0.55 | 5.1e-7 | 6.4e-6 |
Cis-association
Kinase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |
Phosphatase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |