Protein: ENSP00000384600
Gene: CAMKK2

LinkedOmicsKB © 2022-2023 Zhang Lab

CAMKK2:
calcium/calmodulin dependent protein kinase kinase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S25DELGGRGSSSSESQK18----------44--------
S114GGLAAGGSLDMNGRC625839-54--73-5345422319------
Y128CICPSLPYSPVSSPQ827758-2928--27-181028261312--4222-
S129ICPSLPYSPVSSPQS865934-4440--81-744434303229--85377718
S132SLPYSPVSSPQSSPR730524-4939----291644401716--54139
S133LPYSPVSSPQSSPRL838730-44--81-18105498--78338518
S136SPVSSPQSSPRLPRR331--54--18-----------4-
S137PVSSPQSSPRLPRRP841149-44--62-3221353198--48217215
S495KTMIRKRSFGNPFEG888733-4636--99-975793864242--105448918
S509GSRREERSLSAPGNL16------------------6-
Showing 1 to 10 of 12 rows
1025
rows per page

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S25DELGGRGSSSSESQK-----------
S114GGLAAGGSLDMNGRC-3.4e-21------1.8e-14-1.2e-8---
Y128CICPSLPYSPVSSPQ0.97-0.24----0.27----
S129ICPSLPYSPVSSPQS-2.1e-8-7.8e-6---2.1e-6-1.6e-5-4.6e-6--1.4e-3-0.17
S132SLPYSPVSSPQSSPR-0.23-8.9e-8---4.1e-7-0.017----
S133LPYSPVSSPQSSPRL-3.2e-5---------3.6e-7-0.43
S136SPVSSPQSSPRLPRR-----------
S137PVSSPQSSPRLPRRP-0.68-----0.029-0.046--0.270.025
S495KTMIRKRSFGNPFEG-8.6e-3--6.3e-5--9.9e-4-5e-11-1e-10-3.4e-100.3
S509GSRREERSLSAPGNL-----------
Showing 1 to 10 of 12 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationCCRCCS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationCOADS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationGBMS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationHNSCCS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationLSCCS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationLUADS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationOVS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationPDACS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylationUCECS25S114Y128S129S132S133S136S137S495S509S511S572proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.