SOS1: SOS Ras/Rac guanine nucleotide exchange factor 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1awe chain A
1bkd chain S
1dbh chain A
1nvu chain S
1nvv chain S
1nvw chain S
1nvx chain S
1q9c chain A
1q9c chain B
1q9c chain C
1q9c chain D
1q9c chain E
1q9c chain F
1q9c chain G
1q9c chain H
1q9c chain I
1xd2 chain C
1xd4 chain A
1xd4 chain B
1xdv chain A
1xdv chain B
2ii0 chain A
3ksy chain A
4nyi chain S
4nyj chain S
4nym chain S
4uru chain S
4urv chain S
4urw chain S
4urx chain S
4ury chain S
4urz chain S
4us0 chain S
4us1 chain S
4us2 chain S
5ovd chain A
5ove chain A
5ovf chain A
5ovg chain A
5ovh chain A
5ovi chain A
5wfo chain N
5wfp chain N
5wfq chain N
5wfr chain N
6bvi chain B
6bvj chain B
6bvk chain B
6bvl chain B
6bvm chain B
6cuo chain B
6cup chain B
6cur chain B
6d55 chain B
6d56 chain B
6d59 chain B
6d5e chain B
6d5g chain B
6d5h chain B
6d5j chain B
6d5l chain B
6d5m chain S
6d5v chain S
6d5w chain S
6epl chain S
6epm chain S
6epn chain S
6epo chain S
6epp chain S
6f08 chain D
6f08 chain K
6f08 chain N
6f08 chain Q
6scm chain A
6sfr chain A
6sfr chain B
6v94 chain B
6v9f chain B
6v9j chain B
6v9l chain B
6v9m chain B
6v9n chain B
6v9o chain B
6y44 chain P
7avi chain A
7avi chain B
7avl chain A
7avl chain B
7avs chain A
7avs chain B
7avt chain A
7avt chain B
7avu chain A
7avu chain B
7avv chain A
7kfz chain B
7ukr chain A
7ukr chain B
7uks chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S232 VFREPFVS NSKLFSA 1 9 - - - - - - - - 6 3 - - - - - - - - - - S401 SLAKRRLS ESACRFY 10 1480 113 - 103 80 97 100 81 - 102 59 108 97 110 101 54 13 105 44 95 18 S582 YRFAEPDS EENIIFE 2 32 6 - - - - - - - - - 14 12 - - - - - - - - T753 NGPGHNIT FQSSPPT 1 9 - - - - 5 4 - - - - - - - - - - - - - - S757 HNITFQSS PPTVEWH 1 41 - - - - - - 41 - - - - - - - - - - - - - T1054 PGTMRHPT PLQQEPR 2 26 9 - - - - - - - - - - - - - 15 2 - - - - S1078 SETESTAS APNSPRT 9 541 8 - 12 12 24 21 90 - 55 28 55 52 34 31 - - 33 15 64 7 S1082 STASAPNS PRTPLTP 10 912 9 - 12 12 79 82 90 - 63 36 65 61 51 46 75 17 76 31 89 18 S1134 PHGPRSAS VSSISLT 9 809 - - 5 4 86 84 99 - 71 41 59 54 5 4 63 14 96 40 77 7 S1136 GPRSASVS SISLTKG 7 209 47 - 7 7 3 6 - - 25 13 10 9 40 36 - - - - 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S232 VFREPFVS NSKLFSA - - - - - - - - - - - S401 SLAKRRLS ESACRFY 0.56 - -3.8e-3 -2.6e-11 - 9.4e-4 -0.88 1.6e-3 -0.22 4e-10 -0.89 S582 YRFAEPDS EENIIFE - - - - - - - - - - - T753 NGPGHNIT FQSSPPT - - - - - - - - - - - S757 HNITFQSS PPTVEWH - - - - - - - - - - - T1054 PGTMRHPT PLQQEPR - - - - - - - - - - - S1078 SETESTAS APNSPRT -2.5e-12 - - 1 - -0.14 -7.4e-9 -2.5e-3 - -1.8e-4 - S1082 STASAPNS PRTPLTP 0.069 - - -5.6e-6 - 8.1e-10 7.3e-4 0.31 -0.16 -1.2e-5 4.2e-6 S1134 PHGPRSAS VSSISLT -2.9e-9 - - -5e-13 - -6.6e-11 -0.15 - -0.36 4.7e-3 - S1136 GPRSASVS SISLTKG -0.011 - - - - -0.015 - -0.24 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S232
S401
S582
T753
S757
T1054
S1078
S1082
S1134
S1136
S1137
S1139
S1161
S1166
S1167
S1178
S1203
S1205
S1210
T1222
S1229
T1263
S1265
S1275
T1279
T1315
S1318
S1333
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation CCRCC S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation COAD S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation GBM S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation HNSCC S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation LSCC S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation LUAD S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation OV S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation PDAC S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation UCEC S232 S401 S582 T753 S757 T1054 S1078 S1082 S1134 S1136 S1137 S1139 S1161 S1166 S1167 S1178 S1203 S1205 S1210 T1222 S1229 T1263 S1265 S1275 T1279 T1315 S1318 S1333 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S232
S401
S582
T753
S757
T1054
S1078
S1082
S1134
S1136
S1137
S1139
S1161
S1166
S1167
S1178
S1203
S1205
S1210
T1222
S1229
T1263
S1265
S1275
T1279
T1315
S1318
S1333
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S232
S401
S582
T753
S757
T1054
S1078
S1082
S1134
S1136
S1137
S1139
S1161
S1166
S1167
S1178
S1203
S1205
S1210
T1222
S1229
T1263
S1265
S1275
T1279
T1315
S1318
S1333
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.