NCOA1: nuclear receptor coactivator 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1fm6 chain B
1fm6 chain E
1fm6 chain V
1fm6 chain Y
1fm9 chain B
1fm9 chain E
1k4w chain B
1k74 chain B
1k74 chain E
1k7l chain B
1k7l chain D
1k7l chain F
1k7l chain H
1kv6 chain C
1kv6 chain D
1n4h chain B
1nq7 chain B
1nrl chain C
1nrl chain D
1p8d chain C
1p8d chain D
1pzl chain B
1rdt chain B
1tfc chain C
1tfc chain D
1u3r chain C
1u3r chain D
1u3s chain C
1u3s chain D
1x76 chain C
1x76 chain D
1xiu chain E
1xiu chain F
1xv9 chain E
1xv9 chain F
1xv9 chain G
1xv9 chain H
1xvp chain E
1xvp chain F
1xvp chain G
1xvp chain H
1yy4 chain C
1yy4 chain D
1zaf chain C
1zaf chain D
2a3i chain B
2c52 chain B
2fvj chain B
2gtk chain B
2hbh chain B
2hc4 chain B
2hcd chain B
2hfp chain B
2npa chain B
2npa chain D
2nv7 chain C
2nv7 chain D
2p54 chain B
2prg chain C
3bej chain E
3bej chain F
3bqd chain B
3ctb chain A
3ctb chain B
3cwd chain C
3cwd chain D
3dct chain B
3dcu chain B
3dr1 chain B
3et1 chain P
3et1 chain Q
3et3 chain P
3fei chain Z
3fej chain B
3fur chain H
3fxv chain B
3g8i chain Z
3g9e chain B
3gyt chain B
3gyu chain B
3h0a chain B
3h0a chain E
3hc5 chain B
3hc6 chain B
3hvl chain A
3hvl chain B
3ipq chain B
3ips chain C
3ips chain D
3ipu chain C
3ipu chain D
3kmr chain C
3lmp chain C
3okh chain B
3oki chain B
3oki chain D
3olf chain B
3olf chain D
3oll chain C
3oll chain D
3ols chain C
3ols chain D
3omk chain B
3omk chain D
3omm chain B
3omm chain D
3omo chain C
3omo chain D
3omp chain C
3omp chain D
3omq chain C
3omq chain D
3oof chain B
3oof chain D
3ook chain B
3ook chain D
3p88 chain B
3p89 chain B
3qt0 chain C
3rut chain B
3ruu chain B
3rvf chain B
3s9s chain B
3t03 chain C
3t03 chain D
3uu7 chain F
3uu7 chain G
3uua chain F
3uua chain G
3uud chain C
3uud chain D
3v9y chain B
3vn2 chain C
4dk7 chain B
4dk7 chain D
4dk8 chain B
4dk8 chain D
4dm6 chain E
4dm6 chain F
4dm8 chain C
4dm8 chain D
4dqm chain B
4dqm chain D
4f9m chain C
4fgy chain B
4g1d chain B
4g1y chain B
4g1z chain B
4g20 chain B
4g21 chain B
4g2h chain B
4hee chain Y
4j5x chain A
4j5x chain B
4j5x chain C
4j5x chain D
4jyg chain F
4jyg chain G
4jyh chain C
4jyh chain G
4jyi chain F
4jyi chain G
4mg5 chain C
4mg5 chain D
4mg6 chain C
4mg6 chain D
4mg7 chain C
4mg7 chain D
4mg8 chain C
4mg8 chain D
4mg9 chain F
4mg9 chain G
4mga chain C
4mga chain D
4mgb chain C
4mgb chain D
4mgc chain F
4mgc chain G
4mgd chain F
4mgd chain G
4ruj chain B
4rup chain B
4tuz chain F
4tuz chain G
4tv1 chain C
4tv1 chain D
4uda chain B
4udb chain B
4y29 chain B
5a86 chain C
5a86 chain D
5avi chain B
5avi chain D
5avl chain B
5azt chain C
5dsh chain B
5dv3 chain B
5dv6 chain B
5dv8 chain B
5dvc chain B
5dwl chain B
5e7v chain B
5gtn chain B
5gto chain B
5gtp chain B
5hjs chain C
5hjs chain D
5ji0 chain E
5ji0 chain F
5jmm chain F
5jmm chain G
5l7e chain B
5l7g chain B
5l7h chain B
5mwp chain B
5mwy chain B
5mx7 chain B1
5nky chain B
5nma chain B
5nmb chain B2
5nwm chain A
5ow7 chain B
5ow9 chain B
5owd chain B
5q0j chain B
5q0j chain D
5q0k chain B
5q0l chain B
5q0l chain D
5q0m chain B
5q0n chain B
5q0n chain D
5q0o chain B
5q0o chain D
5q0p chain B
5q0p chain D
5q0q chain B
5q0q chain D
5q0r chain B
5q0s chain B
5q0s chain D
5q0t chain B
5q0u chain B
5q0u chain D
5q0v chain B
5q0v chain D
5q0w chain B
5q0x chain B
5q0y chain B
5q0y chain D
5q0z chain B
5q0z chain D
5q10 chain B
5q11 chain B
5q12 chain B
5q13 chain B
5q13 chain D
5q14 chain B
5q14 chain D
5q15 chain B
5q15 chain D
5q16 chain B
5q16 chain D
5q18 chain B
5q18 chain D
5q19 chain B
5q19 chain D
5q1a chain B
5q1a chain D
5q1b chain B
5q1b chain D
5q1c chain B
5q1c chain D
5q1d chain B
5q1d chain D
5q1e chain B
5q1f chain B
5q1f chain D
5q1g chain B
5q1h chain B
5q1h chain D
5q1h chain F
5q1h chain H
5q1i chain B
5x0r chain C
5x0r chain D
5x8u chain B
5x8w chain B
5y44 chain B
5ycn chain B
5ycp chain B
5yp6 chain B
6a5w chain B
6a5w chain D
6a5x chain B
6a5y chain B
6a5y chain F
6a5z chain E
6a5z chain F
6a5z chain G
6a5z chain I
6a60 chain B
6a60 chain F
6bns chain A
6bns chain B
6e3g chain C
6e3g chain D
6fo7 chain B
6fo8 chain B
6fo9 chain B
6fob chain B
6fod chain B
6gev chain B
6gg8 chain B
6hty chain A
6hty chain B
6icj chain B
6ijr chain B
6ijr chain D
6ijs chain B
6ilq chain B
6itm chain B
6itm chain D
6jnr chain C
6jnr chain D
6jq7 chain B
6ktm chain B
6ktn chain B
6l6k chain B
6l96 chain C
6nx1 chain A
6nx1 chain B
6p9f chain A
6p9f chain B
6ssq chain F
6ssq chain G
6t2m chain B
6tfi chain A
6tfi chain B
6u25 chain A
6w9h chain A
6w9i chain A
6xp9 chain A
6xp9 chain B
7aos chain C
7aos chain D
7b39 chain B
7bns chain B2
7bnu chain B2
7bo6 chain B
7bpy chain B
7bpy chain D
7bpz chain B
7bpz chain D
7bq0 chain B
7bq0 chain D
7bq1 chain B
7bq2 chain B
7bq3 chain B
7bq4 chain B
7c6q chain B
7chg chain A
7chg chain B
7cxf chain B
7cxh chain B
7cxi chain B
7cxj chain B
7cxk chain B
7cxl chain B
7jym chain A
7kxd chain A
7kxe chain A
7kxf chain A
7oxz chain B
7oy4 chain B
7wgo chain B
7wgp chain B
7wgq chain B
7xvy chain C
7xvy chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S22 DSHKRKGS PCDTLAS 10 1073 75 - 48 37 46 43 99 - 52 29 90 81 84 78 43 9 103 43 95 18 T26 RKGSPCDT LASSTEK 1 8 - - - - - - - - - - - - 4 4 - - - - - - S369 HIIDREHS GLSPQDD 3 47 29 - - - - - - - 6 3 - - - - - - 5 4 - - S372 DREHSGLS PQDDTNS 10 925 15 - 17 15 64 61 99 - 75 41 74 66 80 73 83 19 26 11 88 18 S395 PSVNPSIS PAHGVAR 7 490 9 - - - 55 61 90 - 6 4 - - - - 77 17 39 19 95 18 S411 STLPPSNS NMVSTRI 1 9 - - - - - - 9 - - - - - - - - - - - - - S551 MNEGPNNS VGFSASS 2 15 9 - 4 2 - - - - - - - - - - - - - - - - S557 NSVGFSAS SPVLRQM 1 7 - - - - - - - - - - - - - - - - 5 2 - - S558 SVGFSASS PVLRQMS 10 489 27 - 9 8 4 5 85 - 29 18 59 52 31 28 8 2 11 4 91 18 S565 SPVLRQMS SQNSPSR 10 436 13 - 4 4 6 3 62 - 16 11 49 45 32 27 21 5 30 12 87 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S22 DSHKRKGS PCDTLAS -3.5e-13 - -8.3e-4 0.52 - -2.2e-4 0.028 -3.2e-3 - -1.8e-18 -8.4e-4 T26 RKGSPCDT LASSTEK - - - - - - - - - - - S369 HIIDREHS GLSPQDD - - - - - - - - - - - S372 DREHSGLS PQDDTNS -4.7e-3 - - -0.014 - 0.27 -0.59 -0.48 -0.032 -0.051 -0.43 S395 PSVNPSIS PAHGVAR 0.36 - - 0.17 - - - - -0.68 0.013 -0.11 S411 STLPPSNS NMVSTRI - - - - - - - - - - - S551 MNEGPNNS VGFSASS - - - - - - - - - - - S557 NSVGFSAS SPVLRQM - - - - - - - - - - - S558 SVGFSASS PVLRQMS -7.7e-13 - - - - -1.2e-4 -7.9e-8 -9.4e-3 - - -0.012 S565 SPVLRQMS SQNSPSR 0.11 - - - - - 8.4e-3 -0.079 - 0.056 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S22
T26
S369
S372
S395
S411
S551
S557
S558
S565
S566
S569
S571
S698
S700
T763
S863
S997
S999
S1372
T1426
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation CCRCC S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation COAD S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation GBM S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation HNSCC S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation LSCC S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation LUAD S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation OV S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation PDAC S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation UCEC S22 T26 S369 S372 S395 S411 S551 S557 S558 S565 S566 S569 S571 S698 S700 T763 S863 S997 S999 S1372 T1426 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S22
T26
S369
S372
S395
S411
S551
S557
S558
S565
S566
S569
S571
S698
S700
T763
S863
S997
S999
S1372
T1426
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S22
T26
S369
S372
S395
S411
S551
S557
S558
S565
S566
S569
S571
S698
S700
T763
S863
S997
S999
S1372
T1426
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.