Protein: ENSP00000385334
Gene: MAD1L1

LinkedOmicsKB © 2022-2023 Zhang Lab

MAD1L1:
mitotic arrest deficient 1 like 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S420AILGSYDSELTPAEY19------------------72
T423GSYDSELTPAEYSPQ716242-1616----5314139871--244
S428ELTPAEYSPQLTRRM7596----908999-171054--661573308216
Showing 1 to 3 of 3 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S420AILGSYDSELTPAEY-----------
T423GSYDSELTPAEYSPQ-----------
S428ELTPAEYSPQLTRRM3.9e-6--1.7e-5----0.123.8e-5-0.44
Showing 1 to 3 of 3 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK1S4281.5e-7--7.3e-30.0160.5--3.0e-40.360.011
Tumor Purity (ABSOLUTE)S4285.5e-5--0.310.760.1--0.135.5e-50.17
KINASE-PSP_JNK1/MAPK8S4281.6e-4---1.1e-4-----0.14
KINASE-PSP_CDK2S4282.5e-4--0.0970.054-0.81--2.6e-3-0.936.7e-3
chromosomal instabilityS4285.1e-4--0.71-0.610.16--1.1e-35.7e-40.59
Tumor Purity (WGS)S4287.9e-4---0.690.017---1.3e-30.48
KINASE-PSP_mTOR/MTORS4281.2e-3---0.090.36----2.8e-3
KINASE-PSP_CDK5S4281.4e-3----0.680.67---2.1e-50.035
HALLMARK_E2F_TARGETSS4281.5e-3--0.180.039-0.88--0.120.816.6e-3
HALLMARK_G2M_CHECKPOINTS4283.2e-3--0.510.0450.97--0.250.851.6e-3
Showing 1 to 10 of 774 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS420T423S428proteinRNASCNVmethylationCCRCCS420T423S428proteinRNASCNVmethylationCOADS420T423S428proteinRNASCNVmethylationGBMS420T423S428proteinRNASCNVmethylationHNSCCS420T423S428proteinRNASCNVmethylationLSCCS420T423S428proteinRNASCNVmethylationLUADS420T423S428proteinRNASCNVmethylationOVS420T423S428proteinRNASCNVmethylationPDACS420T423S428proteinRNASCNVmethylationUCECS420T423S428proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PLPP3S428-9.2e-8---3.4e-3-0.026-0.29--0.84-6.4e-6-0.011
PTPRCS428-4.8e-6--0.550.12-4.4e-3---3.5e-3-1.3e-5-1.3e-3
TNS2S428-1.3e-5---0.027-0.39-0.25---9.1e-3-2.7e-3-0.39
PPP3CCS428-3.1e-5----2.7e-3-0.028---1.1e-3-0.6-0.73
PPM1KS428-2.9e-4----5.3e-4-0.29---0.71-3.0e-60.15
INPP5AS428-3.1e-4---0.48-0.1-0.56---0.3-4.2e-3-0.046
ALPPS428-3.2e-4---------0.3-5.0e-5
PIP4P2S428-6.8e-4---0.47-0.18-0.012---0.085-0.067-0.87
ALPGS428-6.8e-4---------0.017-0.015
PPP3CBS428-8.7e-4---0.13-7.9e-4-0.31---0.005-0.910.53
Showing 1 to 10 of 720 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.