MAST4: microtubule associated serine/threonine kinase family member 4
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2w7r chain A
2w7r chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S114 APRGSSAS QEEQDEE 5 46 13 - 5 4 - - - - 5 3 4 4 4 4 - - - - - - S127 EELDHILS PPPMPFR 3 34 - - 16 - - - - - 5 3 5 5 - - - - - - - - S137 PMPFRKCS NPDVASG 9 656 56 - 37 36 - - 81 - 46 29 29 27 35 32 43 9 79 33 66 18 S156 LKYKRQLS EDGRQLR 8 1091 89 - 103 80 - - 64 - 102 59 108 99 106 97 - - 100 42 29 13 S166 GRQLRRGS LGGALTG 9 939 113 - 59 45 - - 36 - 54 34 108 99 97 89 34 9 43 19 91 9 S206 RSQALGQS APSLTAS 9 1172 105 - 87 80 - - 99 - 108 62 103 94 110 101 43 9 52 21 89 9 S209 ALGQSAPS LTASLKE 4 83 23 - 17 8 - - - - - - 5 4 14 12 - - - - - - T211 GQSAPSLT ASLKELS 4 83 23 - 17 8 - - - - - - 5 4 14 12 - - - - - - S213 SAPSLTAS LKELSLP 6 240 9 - - - - - 27 - 29 17 24 22 - - - - 19 10 65 18 S248 PALPRPHS PLSAHAG 5 251 - - - - - - 18 - 103 59 5 4 10 8 - - - - 35 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S114 APRGSSAS QEEQDEE - - - - - - - - - - - S127 EELDHILS PPPMPFR - - - - - - - - - - - S137 PMPFRKCS NPDVASG 0.75 - 7.8e-14 - - 3.7e-5 -2.5e-7 -0.96 - -7.4e-9 0.86 S156 LKYKRQLS EDGRQLR -7.6e-3 - 3.1e-7 - - 2.7e-9 -1.1e-17 -0.098 - -2.5e-12 -0.71 S166 GRQLRRGS LGGALTG -0.55 - 3.3e-9 - - -0.67 -4e-14 0.38 - -0.88 - S206 RSQALGQS APSLTAS -1.3e-16 - -0.035 - - -0.082 -1.8e-25 -0.21 - -0.003 - S209 ALGQSAPS LTASLKE - - - - - - - - - - - T211 GQSAPSLT ASLKELS - - - - - - - - - - - S213 SAPSLTAS LKELSLP 0.21 - - - - 0.035 -0.051 - - - 0.046 S248 PALPRPHS PLSAHAG -1.3e-3 - - - - -1.3e-3 - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S114
S127
S137
S156
S166
S206
S209
T211
S213
S248
S251
S257
S261
S266
S268
S270
S353
S355
S357
S361
S913
S914
S922
S972
S973
S1126
S1131
S1259
S1275
S1283
S1292
S1293
S1296
S1300
T1302
S1370
S1377
T1382
S1384
T1386
T1390
S1391
S1395
S1397
S1419
S1446
S1451
S1467
S1523
S1554
S1559
T1586
S1652
S1694
S1779
S1796
S1822
S1825
S1828
S1830
S1845
S1846
S1860
S1869
S1909
S1947
S1962
S1997
S2091
S2154
S2213
S2235
S2245
T2253
S2357
S2440
S2442
S2448
S2460
S2462
S2464
S2520
S2552
T2554
S2617
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation CCRCC S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation COAD S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation GBM S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation HNSCC S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation LSCC S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation LUAD S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation OV S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation PDAC S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation UCEC S114 S127 S137 S156 S166 S206 S209 T211 S213 S248 S251 S257 S261 S266 S268 S270 S353 S355 S357 S361 S913 S914 S922 S972 S973 S1126 S1131 S1259 S1275 S1283 S1292 S1293 S1296 S1300 T1302 S1370 S1377 T1382 S1384 T1386 T1390 S1391 S1395 S1397 S1419 S1446 S1451 S1467 S1523 S1554 S1559 T1586 S1652 S1694 S1779 S1796 S1822 S1825 S1828 S1830 S1845 S1846 S1860 S1869 S1909 S1947 S1962 S1997 S2091 S2154 S2213 S2235 S2245 T2253 S2357 S2440 S2442 S2448 S2460 S2462 S2464 S2520 S2552 T2554 S2617 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S114
S127
S137
S156
S166
S206
S209
T211
S213
S248
S251
S257
S261
S266
S268
S270
S353
S355
S357
S361
S913
S914
S922
S972
S973
S1126
S1131
S1259
S1275
S1283
S1292
S1293
S1296
S1300
T1302
S1370
S1377
T1382
S1384
T1386
T1390
S1391
S1395
S1397
S1419
S1446
S1451
S1467
S1523
S1554
S1559
T1586
S1652
S1694
S1779
S1796
S1822
S1825
S1828
S1830
S1845
S1846
S1860
S1869
S1909
S1947
S1962
S1997
S2091
S2154
S2213
S2235
S2245
T2253
S2357
S2440
S2442
S2448
S2460
S2462
S2464
S2520
S2552
T2554
S2617
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S114
S127
S137
S156
S166
S206
S209
T211
S213
S248
S251
S257
S261
S266
S268
S270
S353
S355
S357
S361
S913
S914
S922
S972
S973
S1126
S1131
S1259
S1275
S1283
S1292
S1293
S1296
S1300
T1302
S1370
S1377
T1382
S1384
T1386
T1390
S1391
S1395
S1397
S1419
S1446
S1451
S1467
S1523
S1554
S1559
T1586
S1652
S1694
S1779
S1796
S1822
S1825
S1828
S1830
S1845
S1846
S1860
S1869
S1909
S1947
S1962
S1997
S2091
S2154
S2213
S2235
S2245
T2253
S2357
S2440
S2442
S2448
S2460
S2462
S2464
S2520
S2552
T2554
S2617
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.