MARK2: microtubule affinity regulating kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3iec chain A
3iec chain B
3iec chain C
3iec chain D
5eak chain A
5eak chain B
5kz7 chain A
5kz7 chain B
5kz8 chain A
5kz8 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T6 __MSSART PLPTLNE 2 13 - - - - - - - - - - - - 5 4 - - - - 4 - S26 PTLGHLDS KPSSKSN 1 8 - - 4 4 - - - - - - - - - - - - - - - - S29 GHLDSKPS SKSNMIR 5 88 - - - - - - 18 - 16 10 9 8 4 4 - - 15 4 - - S30 HLDSKPSS KSNMIRG 6 65 - - - - - - 18 - 5 4 5 5 - - 7 1 5 3 12 - S40 NMIRGRNS ATSADEQ 7 486 - - - - - - 99 - 50 29 15 14 4 4 60 14 75 30 79 13 T42 IRGRNSAT SADEQPH 4 69 - - 4 4 - - - - 16 9 5 5 13 13 - - - - - - S43 RGRNSATS ADEQPHI 7 393 - - 27 27 - - 18 - 92 52 50 45 5 4 53 14 - - 6 - S93 KTQLNSSS LQKLFRE 1 9 - - - - - - - - - - - - - - - - - - 7 2 S365 YLLLGYKS SELEGDT 8 938 - - 78 64 - - 99 - 55 33 98 91 93 85 47 13 47 22 95 18 S380 ITLKPRPS ADLTNSS 4 141 - - - - - - 36 - 35 21 5 4 21 19 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T6 __MSSART PLPTLNE - - - - - - - - - - - S26 PTLGHLDS KPSSKSN - - - - - - - - - - - S29 GHLDSKPS SKSNMIR - - - - - - - - - - - S30 HLDSKPSS KSNMIRG - - - - - - - - - - - S40 NMIRGRNS ATSADEQ 0.99 - - - - -0.57 - - 0.91 1.2e-4 -8.0e-4 T42 IRGRNSAT SADEQPH - - - - - - - - - - - S43 RGRNSATS ADEQPHI -0.18 - -0.62 - - 0.18 -3.4e-3 - -0.55 - - S93 KTQLNSSS LQKLFRE - - - - - - - - - - - S365 YLLLGYKS SELEGDT -3e-7 - -3.0e-6 - - -1.8e-10 -0.16 -5.4e-7 0.044 -0.072 2.2e-4 S380 ITLKPRPS ADLTNSS -0.47 - - - - 0.69 - -0.15 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T6
S26
S29
S30
S40
T42
S43
S93
S365
S380
S387
S390
S398
S400
S409
T419
S420
S422
S456
T466
T467
T469
S471
T472
T478
S479
S483
S486
S493
S498
S505
S514
T515
S517
S519
S533
S535
S537
S551
S559
T560
S569
S571
S595
T596
T616
S619
S624
S631
S633
S675
S722
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation CCRCC T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation COAD T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation GBM T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation HNSCC T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation LSCC T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation LUAD T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation OV T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation PDAC T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation UCEC T6 S26 S29 S30 S40 T42 S43 S93 S365 S380 S387 S390 S398 S400 S409 T419 S420 S422 S456 T466 T467 T469 S471 T472 T478 S479 S483 S486 S493 S498 S505 S514 T515 S517 S519 S533 S535 S537 S551 S559 T560 S569 S571 S595 T596 T616 S619 S624 S631 S633 S675 S722 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T6
S26
S29
S30
S40
T42
S43
S93
S365
S380
S387
S390
S398
S400
S409
T419
S420
S422
S456
T466
T467
T469
S471
T472
T478
S479
S483
S486
S493
S498
S505
S514
T515
S517
S519
S533
S535
S537
S551
S559
T560
S569
S571
S595
T596
T616
S619
S624
S631
S633
S675
S722
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
T6
S26
S29
S30
S40
T42
S43
S93
S365
S380
S387
S390
S398
S400
S409
T419
S420
S422
S456
T466
T467
T469
S471
T472
T478
S479
S483
S486
S493
S498
S505
S514
T515
S517
S519
S533
S535
S537
S551
S559
T560
S569
S571
S595
T596
T616
S619
S624
S631
S633
S675
S722
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.