Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2k86 chain A
2lqh chain B
2lqi chain B
2uzk chain A
2uzk chain C
6mnl chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S75 DGGGRAGS AMAIGGG 8 275 32 - 4 4 4 5 - - - - 5 4 75 70 6 2 5 2 53 4 S85 AIGGGGGS GTLGSGL 4 74 18 - - - - - - - 6 3 14 13 - - - - - - 18 2 T87 GGGGGSGT LGSGLLL 4 37 16 - - - - - - - - - 4 4 4 4 - - 3 2 - - S90 GGSGTLGS GLLLEDS 2 34 - - - - - - - - - - 10 10 - - - - - - 12 2 S173 ITRAIESS PDKRLTL 1 9 9 - - - - - - - - - - - - - - - - - - - S215 NSIRHNLS LHSRFMR 6 377 40 - 32 22 - - 72 - - - 39 36 48 43 - - - - 41 4 S253 APRRRAVS MDNSNKY 10 1508 122 - 103 80 75 77 99 - 108 62 108 99 110 101 83 19 105 44 95 18 S280 ALQTAPES ADDSPSQ 8 394 61 - 29 19 - - 9 - 30 16 85 79 22 20 7 1 - - 16 - S284 APESADDS PSQLSKW 10 1236 105 - 90 70 55 61 81 - 80 47 83 77 79 73 68 17 105 44 83 18 S286 ESADDSPS QLSKWPG 1 23 - - - - - - - - - - - - - - - - - - 12 11
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S75 DGGGRAGS AMAIGGG -0.17 - - - - - - -0.17 - - - S85 AIGGGGGS GTLGSGL - - - - - - - - - - - T87 GGGGGSGT LGSGLLL - - - - - - - - - - - S90 GGSGTLGS GLLLEDS - - - - - - - - - - - S173 ITRAIESS PDKRLTL - - - - - - - - - - - S215 NSIRHNLS LHSRFMR 0.17 - 0.42 - - - -0.56 0.032 - - - S253 APRRRAVS MDNSNKY -9e-7 - 9.5e-19 -0.33 - -2.5e-3 -1.5e-6 -2.2e-7 -0.4 -2.6e-17 0.23 S280 ALQTAPES ADDSPSQ -9.9e-8 - 8.3e-4 - - -0.019 -1.3e-12 -5.1e-6 - - - S284 APESADDS PSQLSKW 2.8e-20 - 3.1e-15 0.035 - 4.9e-3 7.2e-11 2e-7 -0.042 0.45 4.3e-3 S286 ESADDSPS QLSKWPG - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S75
S85
T87
S90
S173
S215
S253
S280
S284
S286
S294
T296
S297
S299
S300
S311
S315
S318
S325
S344
Y348
S355
S399
S402
S411
S413
S425
T427
S429
S432
T433
S438
S439
S446
S553
S555
S574
S630
S644
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation CCRCC S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation COAD S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation GBM S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation HNSCC S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation LSCC S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation LUAD S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation OV S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation PDAC S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation UCEC S75 S85 T87 S90 S173 S215 S253 S280 S284 S286 S294 T296 S297 S299 S300 S311 S315 S318 S325 S344 S355 S399 S402 S411 S413 S425 T427 S429 S432 T433 S438 S439 S446 S553 S555 S574 S630 S644 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S75
S85
T87
S90
S173
S215
S253
S280
S284
S286
S294
T296
S297
S299
S300
S311
S315
S318
S325
S344
Y348
S355
S399
S402
S411
S413
S425
T427
S429
S432
T433
S438
S439
S446
S553
S555
S574
S630
S644
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S75
S85
T87
S90
S173
S215
S253
S280
S284
S286
S294
T296
S297
S299
S300
S311
S315
S318
S325
S344
Y348
S355
S399
S402
S411
S413
S425
T427
S429
S432
T433
S438
S439
S446
S553
S555
S574
S630
S644
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.