DAPK1: death associated protein kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1ig1 chain A
1jkk chain A
1jkl chain A
1jks chain A
1jkt chain A
1jkt chain B
1p4f chain A
1wvw chain A
1wvx chain A
1wvy chain A
1yr5 chain B
2w4j chain A
2w4k chain A
2x0g chain A
2xuu chain A
2xzs chain A
2xzs chain B
2y0a chain A
2y4p chain A
2y4p chain B
2y4p chain C
2y4p chain D
2y4v chain B
2yak chain A
3dfc chain B
3dgk chain A
3eh9 chain A
3eha chain A
3f5g chain A
3f5u chain A
3gu4 chain A
3gu5 chain A
3gu6 chain A
3gu7 chain A
3gu8 chain A
3gub chain A
3zxt chain A
3zxt chain B
3zxt chain C
3zxt chain D
4b4l chain A
4pf4 chain A
4tl0 chain A
4txc chain A
4uv0 chain A
4yo4 chain A
4ypd chain A
5aut chain A
5auu chain A
5auv chain A
5auw chain A
5aux chain A
5auy chain A
5auz chain A
5av0 chain A
5av1 chain A
5av2 chain A
5av3 chain A
5av4 chain A
6aar chain A
6fha chain A
6fhb chain A
6gy5 chain U
6in4 chain A
6qmo chain A
6qn4 chain A
7ccu chain A
7ccv chain A
7ccw chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S285 KDTQQALS RKASAVN 7 183 17 - 42 22 - - 9 - - - 19 16 14 12 7 1 18 6 - - S289 QALSRKAS AVNMEKF 10 1417 122 - 99 76 75 60 99 - 98 55 108 99 110 101 68 16 105 44 64 18 S313 KQSVRLIS LCQRLSR 1 17 - - - - - - - - - - - - - - 15 2 - - - - S319 ISLCQRLS RSFLSRS 7 770 87 - 90 68 - - - - 57 35 88 80 91 84 - - 51 21 7 11 S321 LCQRLSRS FLSRSNM 1 16 - - 12 4 - - - - - - - - - - - - - - - - S324 RLSRSFLS RSNMSVA 3 124 - - 14 12 - - - - - - 29 26 21 22 - - - - - - S326 SRSFLSRS NMSVARS 9 737 45 - 38 25 12 14 45 - - - 108 99 98 89 62 14 32 15 34 7 S333 SNMSVARS DDTLDEE 7 282 9 - - - 10 8 53 - - - 10 9 30 28 35 7 - - 74 9 T336 SVARSDDT LDEEDSF 6 322 8 - - - - - - - 5 3 74 67 72 64 - - 5 2 18 4 S366 GLQHLLGS LSNYDVN 6 57 8 - 7 6 - - - - 6 4 5 4 5 4 - - 6 2 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S285 KDTQQALS RKASAVN 0.15 - 0.15 - - - - - - - - S289 QALSRKAS AVNMEKF -0.36 - 9.5e-8 1.5e-3 - 6.1e-11 -5.6e-22 -1.2e-11 7.5e-5 -0.6 -0.37 S313 KQSVRLIS LCQRLSR - - - - - - - - - - - S319 ISLCQRLS RSFLSRS -7.8e-9 - 2.8e-3 - - -3.7e-10 -6.5e-10 -0.043 - -0.15 - S321 LCQRLSRS FLSRSNM - - - - - - - - - - - S324 RLSRSFLS RSNMSVA -8.9e-11 - - - - - -1.6e-4 -6.7e-8 - - - S326 SRSFLSRS NMSVARS -1.3e-13 - -6.1e-4 - - - -3e-25 -8e-16 0.22 4.6e-5 - S333 SNMSVARS DDTLDEE 0.002 - - - - - - 0.002 - - - T336 SVARSDDT LDEEDSF -2.1e-9 - - - - - -1e-9 -0.018 - - - S366 GLQHLLGS LSNYDVN - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S285
S289
S313
S319
S321
S324
S326
S333
T336
S366
S368
T427
S725
S745
S762
T1053
S1115
S1429
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation CCRCC S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation COAD S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation GBM S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation HNSCC S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation LSCC S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation LUAD S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation OV S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation PDAC S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation UCEC S285 S289 S313 S319 S321 S324 S326 S333 T336 S366 S368 T427 S725 S745 S762 T1053 S1115 S1429 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S285
S289
S313
S319
S321
S324
S326
S333
T336
S366
S368
T427
S725
S745
S762
T1053
S1115
S1429
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S285
S289
S313
S319
S321
S324
S326
S333
T336
S366
S368
T427
S725
S745
S762
T1053
S1115
S1429
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.