SETD2: SET domain containing 2, histone lysine methyltransferase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2a7o chain A
2mdc chain A
2mdi chain A
2mdj chain A
4fmu chain A
4h12 chain A
5jjy chain A
5jlb chain A
5jle chain A
5lss chain A
5lsx chain A
5lsy chain A
5lsz chain A
5lt6 chain A
5lt6 chain B
5lt7 chain A
5lt8 chain A
5v21 chain A
5v22 chain A
6j9j chain A
6vdb chain A
7ea8 chain L
7evr chain B
7evr chain D
7evs chain C
7evs chain D
7lzb chain A
7lzd chain A
7lzf chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T126 EIGDTLST AEESSPP 1 10 - - - - - - - - - - 5 5 - - - - - - - - S130 TLSTAEES SPPKSRV 6 115 41 - 16 16 - - - - - - 5 4 9 8 6 2 - - 6 2 S131 LSTAEESS PPKSRVE 10 827 30 - 8 - 64 53 55 - 68 41 68 61 25 24 76 15 90 36 95 18 S249 PIIIVPES LEADTKQ 1 10 - - - - - - - - - - 5 5 - - - - - - - - S262 KQDTISNS LEEHVTQ 1 8 - - - - - - - - - - 4 4 - - - - - - - - S321 SEGIFLGS ESDEDSV 10 613 71 - 25 16 29 33 90 - 18 9 54 48 57 52 40 10 5 2 45 9 S323 GIFLGSES DEDSVRT 10 662 24 - 28 20 19 17 72 - 45 28 59 55 62 58 31 10 35 13 70 16 S332 EDSVRTSS SQRSHDL 1 9 - - - - - - 9 - - - - - - - - - - - - - S333 DSVRTSSS QRSHDLK 3 84 - - - - - - 9 - - - 5 5 - - - - - - 49 16 S336 RTSSSQRS HDLKFSA 3 93 - - - - - - 18 - - - 5 5 - - - - - - 49 16
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T126 EIGDTLST AEESSPP - - - - - - - - - - - S130 TLSTAEES SPPKSRV - - - - - - - - - - - S131 LSTAEESS PPKSRVE 1.2e-6 - - 0.13 - 1.1e-3 2.4e-10 6.8e-3 -0.37 -1.3e-3 1.8e-3 S249 PIIIVPES LEADTKQ - - - - - - - - - - - S262 KQDTISNS LEEHVTQ - - - - - - - - - - - S321 SEGIFLGS ESDEDSV 9.7e-3 - -5.3e-9 0.053 - - 1.2e-7 2.5e-6 -0.75 - - S323 GIFLGSES DEDSVRT 0.91 - -6.9e-4 - - 0.31 1.2e-6 -0.58 -0.25 -0.58 0.93 S332 EDSVRTSS SQRSHDL - - - - - - - - - - - S333 DSVRTSSS QRSHDLK 0.076 - - - - - - - - - 0.076 S336 RTSSSQRS HDLKFSA 0.076 - - - - - - - - - 0.076
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T126
S130
S131
S249
S262
S321
S323
S332
S333
S336
S344
Y419
S422
S438
S447
S458
S459
S461
Y465
S474
S479
T521
S522
S532
S543
S572
T576
S587
S614
S618
S624
S645
S648
S676
S681
T697
S698
S701
T703
S705
S708
S742
S744
T749
S754
S784
S800
S807
S905
S918
S980
S1068
T1083
S1084
S1098
S1206
S1207
S1228
S1347
S1350
S1353
S1413
S1415
S1417
S1696
S1714
S1838
Y1843
S1844
S1845
T1848
S1849
T1853
T1857
T1872
S1885
S1888
S1891
S1894
S1898
S1925
S1952
T1978
S1980
S1988
S1992
S1995
T2056
S2060
S2079
S2080
S2082
T2101
S2117
T2421
S2424
S2430
T2441
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation CCRCC T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation COAD T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation GBM T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation HNSCC T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation LSCC T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation LUAD T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation OV T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation PDAC T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation UCEC T126 S130 S131 S249 S262 S321 S323 S332 S333 S336 S344 Y419 S422 S438 S447 S458 S459 S461 Y465 S474 S479 T521 S522 S532 S543 S572 T576 S587 S614 S618 S624 S645 S648 S676 S681 T697 S698 S701 T703 S705 S708 S742 S744 T749 S754 S784 S800 S807 S905 S918 S980 S1068 T1083 S1084 S1098 S1206 S1207 S1228 S1347 S1350 S1353 S1413 S1415 S1417 S1696 S1714 S1838 Y1843 S1844 S1845 T1848 S1849 T1853 T1857 T1872 S1885 S1888 S1891 S1894 S1898 S1925 S1952 T1978 S1980 S1988 S1992 S1995 T2056 S2060 S2079 S2080 S2082 T2101 S2117 T2421 S2424 S2430 T2441 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T126
S130
S131
S249
S262
S321
S323
S332
S333
S336
S344
Y419
S422
S438
S447
S458
S459
S461
Y465
S474
S479
T521
S522
S532
S543
S572
T576
S587
S614
S618
S624
S645
S648
S676
S681
T697
S698
S701
T703
S705
S708
S742
S744
T749
S754
S784
S800
S807
S905
S918
S980
S1068
T1083
S1084
S1098
S1206
S1207
S1228
S1347
S1350
S1353
S1413
S1415
S1417
S1696
S1714
S1838
Y1843
S1844
S1845
T1848
S1849
T1853
T1857
T1872
S1885
S1888
S1891
S1894
S1898
S1925
S1952
T1978
S1980
S1988
S1992
S1995
T2056
S2060
S2079
S2080
S2082
T2101
S2117
T2421
S2424
S2430
T2441
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
T126
S130
S131
S249
S262
S321
S323
S332
S333
S336
S344
Y419
S422
S438
S447
S458
S459
S461
Y465
S474
S479
T521
S522
S532
S543
S572
T576
S587
S614
S618
S624
S645
S648
S676
S681
T697
S698
S701
T703
S705
S708
S742
S744
T749
S754
S784
S800
S807
S905
S918
S980
S1068
T1083
S1084
S1098
S1206
S1207
S1228
S1347
S1350
S1353
S1413
S1415
S1417
S1696
S1714
S1838
Y1843
S1844
S1845
T1848
S1849
T1853
T1857
T1872
S1885
S1888
S1891
S1894
S1898
S1925
S1952
T1978
S1980
S1988
S1992
S1995
T2056
S2060
S2079
S2080
S2082
T2101
S2117
T2421
S2424
S2430
T2441
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.