MAP3K2: mitogen-activated protein kinase kinase kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2cu1 chain A
2npt chain B
2npt chain D
5ex0 chain D
5hq8 chain I
5hq8 chain J
6ldv chain P
6ldw chain C
6ldw chain D
6ldx chain B
6ldy chain C
6ldy chain M
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S26 KASRPALS LQETRKA 7 217 7 - - - - - - - 7 3 10 9 35 32 22 4 27 11 46 4 S109 AVELLDRS IHMKSLK 3 30 9 - 7 7 - - - - - - - - - - - - 5 2 - - S153 AERKKRLS IIGPTSR 10 1502 122 - 87 65 91 97 98 - 108 62 103 94 110 101 83 19 105 44 95 18 S159 LSIIGPTS RDRSSPP 1 8 - - - - - - - - - - - - - - 7 1 - - - - S163 GPTSRDRS SPPPGYI 3 24 8 - - - - - - - - - - - 4 4 6 2 - - - - S164 PTSRDRSS PPPGYIP 10 1456 122 - 87 64 97 100 99 - 104 58 108 99 91 84 83 19 91 37 95 18 S239 SRMPRAQS YPDNHQE 4 129 - - - - 11 7 45 - - - - - - - 14 4 - - 43 5 Y240 RMPRAQSY PDNHQEF 8 214 - - 5 4 31 23 9 - - - 10 9 9 9 29 5 21 8 37 5 S248 PDNHQEFS DYDNPIF 6 291 60 - 46 36 - - - - 7 2 50 46 19 16 - - - - - 9 S271 YPRRYHVS YHHQEYN 4 112 9 - - - - - 18 - - - 5 4 39 37 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S26 KASRPALS LQETRKA 0.21 - - - - - - -0.65 - 0.025 - S109 AVELLDRS IHMKSLK - - - - - - - - - - - S153 AERKKRLS IIGPTSR 8.0e-5 - 4.5e-23 -1.1e-24 - 6.3e-14 -9.5e-6 -0.77 0.035 2.9e-12 -0.017 S159 LSIIGPTS RDRSSPP - - - - - - - - - - - S163 GPTSRDRS SPPPGYI - - - - - - - - - - - S164 PTSRDRSS PPPGYIP 1.6e-17 - 0.55 0.32 - 1.4e-3 5.2e-7 7.9e-9 0.21 9.6e-8 0.054 S239 SRMPRAQS YPDNHQE - - - - - - - - - - - Y240 RMPRAQSY PDNHQEF 3.8e-3 - - 3.8e-3 - - - - - - - S248 PDNHQEFS DYDNPIF 6.3e-10 - 1.9e-11 - - - 0.043 - - - - S271 YPRRYHVS YHHQEYN 4.2e-4 - - - - - - 4.2e-4 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S26
S109
S153
S159
S163
S164
S239
Y240
S248
S271
T290
S294
S297
S302
T304
S307
T310
S311
S312
S314
S315
S331
T337
T339
S344
S347
S349
S514
T516
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation CCRCC S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation COAD S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation GBM S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation HNSCC S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation LSCC S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation LUAD S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation OV S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation PDAC S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation UCEC S26 S109 S153 S159 S163 S164 S239 Y240 S248 S271 T290 S294 S297 S302 T304 S307 T310 S311 S312 S314 S315 S331 T337 T339 S344 S347 S349 S514 T516 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S26
S109
S153
S159
S163
S164
S239
Y240
S248
S271
T290
S294
S297
S302
T304
S307
T310
S311
S312
S314
S315
S331
T337
T339
S344
S347
S349
S514
T516
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S26
S109
S153
S159
S163
S164
S239
Y240
S248
S271
T290
S294
S297
S302
T304
S307
T310
S311
S312
S314
S315
S331
T337
T339
S344
S347
S349
S514
T516
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.