Protein: ENSP00000387911
Gene: PARN

LinkedOmicsKB © 2022-2023 Zhang Lab

PARN:
poly(A)-specific ribonuclease

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S160ANGAGALSYVSPNTS110--------73----------
Y161NGAGALSYVSPNTSK35518-------178------93--
S163AGALSYVSPNTSKCP1079455-1713362728-854945428677461294382816
T341FKDIINNTSLAELEK188-------------------
S342KDIINNTSLAELEKR232----------55------202
S530KRKWTEDSWKEADSK19------------54------
S557NHYYRNNSFTAPSTV881545-31179710081-7644----83198434959
T559YYRNNSFTAPSTVGK320------9---------416-
S570TVGKRNLSPSQEEAG1029825-8-27359-117393345823714322
S572GKRNLSPSQEEAGLE1027215-2828999-3520352612125-1676-
Showing 1 to 10 of 19 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S160ANGAGALSYVSPNTS-----------
Y161NGAGALSYVSPNTSK-----------
S163AGALSYVSPNTSKCP7.2e-20--6.3e-6-8.8e-111.8e-162.7e-7-0.37-0.0910.019
T341FKDIINNTSLAELEK-----------
S342KDIINNTSLAELEKR-----------
S530KRKWTEDSWKEADSK-----------
S557NHYYRNNSFTAPSTV1.0e-6-3.7e-30.016-1.1e-8--0.64-0.58-
T559YYRNNSFTAPSTVGK-----------
S570TVGKRNLSPSQEEAG0.032--3.2e-4--0.35---0.41-
S572GKRNLSPSQEEAGLE0.58--5.2e-4--0.211.4e-3----
Showing 1 to 10 of 19 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationCCRCCS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationCOADS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationGBMS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationHNSCCS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationLSCCS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationLUADS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationOVS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationPDACS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylationUCECS160Y161S163T341S342S530S557T559S570S572S583S587T589T594S619S623S628T631T638proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.