EIF4E: eukaryotic translation initiation factor 4E
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1ipb chain A
1ipc chain A
1wkw chain A
2gpq chain A
2v8w chain A
2v8w chain E
2v8x chain A
2v8x chain E
2v8y chain A
2v8y chain E
2w97 chain A
2w97 chain B
3am7 chain A
3tf2 chain A
3tf2 chain B
3tf2 chain C
3tf2 chain D
3u7x chain A
3u7x chain B
4aza chain A
4aza chain C
4bea chain A
4dt6 chain A
4dum chain A
4tpw chain A
4tpw chain B
4tqb chain A
4tqb chain B
4tqc chain A
4tqc chain B
4ued chain A
5ehc chain A
5ei3 chain A
5eir chain A
5ekv chain A
5ekv chain C
5gw6 chain A
5t46 chain A
5t46 chain C
5zjy chain A
5zjz chain A
5zk5 chain A
5zk7 chain A
5zk7 chain B
5zk9 chain A
5zml chain A
7d6y chain A
7d8b chain A
7d8b chain C
7ezw chain A
7f07 chain A
7meu chain A
7meu chain B
7xtp chain A
7xtp chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S24 TEEEKTES NQEVANP 8 941 - - 85 64 - - 91 - 98 54 108 99 48 45 15 3 97 39 79 16
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S24 TEEEKTES NQEVANP 0.77 - -0.19 - - 9.4e-4 0.3 0.85 - -0.47 -0.076
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S24
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S24 protein RNA SCNV methylation CCRCC S24 protein RNA SCNV methylation COAD S24 protein RNA SCNV methylation GBM S24 protein RNA SCNV methylation HNSCC S24 protein RNA SCNV methylation LSCC S24 protein RNA SCNV methylation LUAD S24 protein RNA SCNV methylation OV S24 protein RNA SCNV methylation PDAC S24 protein RNA SCNV methylation UCEC S24 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S24
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S24
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.