HERC1: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4o2w chain A
4o2w chain B
4o2w chain C
4o2w chain D
4qt6 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S133 KVKQQQHS PESSSGS 1 41 - - - - - - 41 - - - - - - - - - - - - - S1328 SSRDRWIS ENQDSAD 4 141 - - 4 4 - - 72 - - - - - - - 44 8 - - - 9 S1333 WISENQDS ADVDPQE 7 245 - - 8 7 - - 73 - 6 3 25 23 41 35 6 2 - - 11 5 S1342 DVDPQEHS FTRTIDE 6 144 8 - - - - - 26 - - - 25 22 5 4 7 1 - - 44 2 S1406 RDRDRMNS GAGSGAR 7 735 36 - - - - - 99 - - - 93 85 69 65 62 11 102 42 62 9 S1410 RMNSGAGS GARADDP 2 44 - - - - - - - - - - 19 17 5 3 - - - - - - S1428 SQQERRVS TDLPEGQ 10 710 64 - 17 16 21 32 79 - 46 26 49 47 31 26 66 11 67 27 67 18 T1429 QQERRVST DLPEGQD 3 51 - - - - 7 11 - - 5 3 - - 13 12 - - - - - - S1491 GLMTRSES LTAESRL 8 714 - - - - 83 87 99 - 48 26 30 27 10 8 71 14 97 40 58 16 S1502 ESRLVHTS PNYRLIK 3 30 - - - - - - - - 5 3 - - - - 7 2 - - 11 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S133 KVKQQQHS PESSSGS - - - - - - - - - - - S1328 SSRDRWIS ENQDSAD - - - - - - - - - - - S1333 WISENQDS ADVDPQE -0.36 - - - - - -0.92 -0.23 - - - S1342 DVDPQEHS FTRTIDE 0.09 - - - - - 0.09 - - - - S1406 RDRDRMNS GAGSGAR -0.015 - - - - - -9.5e-9 -0.062 0.1 0.28 - S1410 RMNSGAGS GARADDP - - - - - - - - - - - S1428 SQQERRVS TDLPEGQ 7.9e-4 - - 0.98 - 1.5e-3 0.019 0.069 0.025 0.25 -0.059 T1429 QQERRVST DLPEGQD - - - - - - - - - - - S1491 GLMTRSES LTAESRL 1.3e-5 - - 0.016 - 5e-11 7.7e-7 - -4.5e-3 1.5e-3 -3.5e-4 S1502 ESRLVHTS PNYRLIK - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S133
S1328
S1333
S1342
S1406
S1410
S1428
T1429
S1491
S1502
S1510
S1512
S1514
S1517
S1521
S1541
S1575
S1578
S1881
S2422
T2471
S2474
S2477
S2545
T2701
S2705
S2706
T2709
S2710
S2720
T2722
S2723
S2738
T2746
S2747
S3071
Y3073
S3238
S3483
S3485
S4857
T4859
Y4861
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation CCRCC S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation COAD S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation GBM S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation HNSCC S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation LSCC S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation LUAD S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation OV S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation PDAC S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation UCEC S133 S1328 S1333 S1342 S1406 S1410 S1428 T1429 S1491 S1502 S1510 S1512 S1514 S1517 S1521 S1541 S1575 S1578 S1881 S2422 T2471 S2474 S2477 S2545 T2701 S2705 S2706 T2709 S2710 S2720 T2722 S2723 S2738 T2746 S2747 S3071 Y3073 S3238 S3483 S3485 S4857 T4859 Y4861 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S133
S1328
S1333
S1342
S1406
S1410
S1428
T1429
S1491
S1502
S1510
S1512
S1514
S1517
S1521
S1541
S1575
S1578
S1881
S2422
T2471
S2474
S2477
S2545
T2701
S2705
S2706
T2709
S2710
S2720
T2722
S2723
S2738
T2746
S2747
S3071
Y3073
S3238
S3483
S3485
S4857
T4859
Y4861
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S133
S1328
S1333
S1342
S1406
S1410
S1428
T1429
S1491
S1502
S1510
S1512
S1514
S1517
S1521
S1541
S1575
S1578
S1881
S2422
T2471
S2474
S2477
S2545
T2701
S2705
S2706
T2709
S2710
S2720
T2722
S2723
S2738
T2746
S2747
S3071
Y3073
S3238
S3483
S3485
S4857
T4859
Y4861
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.