PLEKHG2: pleckstrin homology and RhoGEF domain containing G2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S45 PAAPTMAS PRGSGSS 1 12 - - - - - - - - - - - - - - - - - - 12 - S49 TMASPRGS GSSTSLS 6 77 - - - - - - 26 - 5 2 5 4 11 9 - - 6 2 7 - S51 ASPRGSGS STSLSTV 2 43 - - - - - - - - - - - - - - - - 4 4 22 13 S52 SPRGSGSS TSLSTVG 1 6 - - - - - - - - - - - - - - - - - - 6 - T53 PRGSGSST SLSTVGS 2 13 - - 3 3 - - 7 - - - - - - - - - - - - - S54 RGSGSSTS LSTVGSE 3 32 - - 3 3 - - 7 - - - - - - - - - - - 9 10 S60 TSLSTVGS EGDPAPG 5 92 - - 10 8 - - 8 - 10 7 10 8 - - - - - - 26 5 S90 PPIRLHLS PVGIPGS 7 316 - - 3 3 - - 46 - 18 8 10 9 62 57 - - 8 4 72 16 S437 SLHCAPKS KPVLEPL 1 8 - - - - - - - - - - - - - - - - - - 8 - T445 KPVLEPLT PPLGSPR 7 1075 - - 99 76 - - 99 - 102 59 94 86 110 101 - - 101 43 89 16
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S45 PAAPTMAS PRGSGSS - - - - - - - - - - - S49 TMASPRGS GSSTSLS - - - - - - - - - - - S51 ASPRGSGS STSLSTV -0.079 - - - - - - - - - -0.079 S52 SPRGSGSS TSLSTVG - - - - - - - - - - - T53 PRGSGSST SLSTVGS - - - - - - - - - - - S54 RGSGSSTS LSTVGSE - - - - - - - - - - - S60 TSLSTVGS EGDPAPG - - - - - - - - - - - S90 PPIRLHLS PVGIPGS 4.3e-4 - - - - - - 1.3e-5 - - 0.54 S437 SLHCAPKS KPVLEPL - - - - - - - - - - - T445 KPVLEPLT PPLGSPR 3.9e-33 - 3.6e-19 - - 6.2e-8 0.01 2.2e-6 - 2.3e-9 0.081
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S45
S49
S51
S52
T53
S54
S60
S90
S437
T445
S450
T466
S469
S482
S588
S591
S592
S610
S714
S716
S740
T742
S911
S1049
T1051
T1153
T1162
S1163
S1168
T1195
T1212
S1220
S1227
T1229
S1254
T1257
S1261
S1307
S1310
S1314
S1318
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation CCRCC S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation COAD S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation GBM S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation HNSCC S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation LSCC S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation LUAD S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation OV S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation PDAC S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation UCEC S45 S49 S51 S52 T53 S54 S60 S90 S437 T445 S450 T466 S469 S482 S588 S591 S592 S610 S714 S716 S740 T742 S911 S1049 T1051 T1153 T1162 S1163 S1168 T1195 T1212 S1220 S1227 T1229 S1254 T1257 S1261 S1307 S1310 S1314 S1318 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S45
S49
S51
S52
T53
S54
S60
S90
S437
T445
S450
T466
S469
S482
S588
S591
S592
S610
S714
S716
S740
T742
S911
S1049
T1051
T1153
T1162
S1163
S1168
T1195
T1212
S1220
S1227
T1229
S1254
T1257
S1261
S1307
S1310
S1314
S1318
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S45
S49
S51
S52
T53
S54
S60
S90
S437
T445
S450
T466
S469
S482
S588
S591
S592
S610
S714
S716
S740
T742
S911
S1049
T1051
T1153
T1162
S1163
S1168
T1195
T1212
S1220
S1227
T1229
S1254
T1257
S1261
S1307
S1310
S1314
S1318
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.