Protein: ENSP00000393316
Gene: TMX1

LinkedOmicsKB © 2022-2023 Zhang Lab

TMX1:
thioredoxin related transmembrane protein 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S221PQPYPYPSKKLLSES7398--3635422982-5834108----3916-9
S226YPSKKLLSESAQPLK853718---221490-643835331313--60249518
S228SKKLLSESAQPLKKV10111463-6948484299-102598377928519675349518
S247EADEEDVSEEEAESK101553122-103809710099-10862108991101018319105449518
S253VSEEEAESKEGTNKD5176--1212--45-31212523------52
S270QNAIRQRSLGPSLAT10146172-99769710099-108621049596898319105449518
S280PSLATDKS_______732223-88--55---58544136153--174
Showing 1 to 7 of 7 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S221PQPYPYPSKKLLSES5.5e-8-8.9e-54.9e-7-3.7e-8----3.3e-4-
S226YPSKKLLSESAQPLK0.15--0.67-4.7e-6-5.7e-3--0.350.97
S228SKKLLSESAQPLKKV3.7e-18-0.751.1e-9-1.2e-182.3e-166.5e-8--2.8e-4-0.027
S247EADEEDVSEEEAESK6.0e-6-1.6e-40.014-6.4e-93e-81.2e-3-0.29-1.2e-5-9.7e-3
S253VSEEEAESKEGTNKD1.1e-4----0.039.5e-4----
S270QNAIRQRSLGPSLAT0.21-1.5e-17-2.7e-7-2.3e-15-0.0282.7e-5-0.066-2.4e-5-6.5e-4
S280PSLATDKS_______9.2e-25-----1.7e-171.7e-9---
Showing 1 to 7 of 7 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS221S226S228S247S253S270S280proteinRNASCNVmethylationCCRCCS221S226S228S247S253S270S280proteinRNASCNVmethylationCOADS221S226S228S247S253S270S280proteinRNASCNVmethylationGBMS221S226S228S247S253S270S280proteinRNASCNVmethylationHNSCCS221S226S228S247S253S270S280proteinRNASCNVmethylationLSCCS221S226S228S247S253S270S280proteinRNASCNVmethylationLUADS221S226S228S247S253S270S280proteinRNASCNVmethylationOVS221S226S228S247S253S270S280proteinRNASCNVmethylationPDACS221S226S228S247S253S270S280proteinRNASCNVmethylationUCECS221S226S228S247S253S270S280proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.