PDHA1: pyruvate dehydrogenase E1 subunit alpha 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1ni4 chain A
1ni4 chain C
2ozl chain A
2ozl chain C
3exe chain A
3exe chain C
3exe chain E
3exe chain G
3exf chain A
3exf chain C
3exf chain E
3exf chain G
3exg chain 1
3exg chain 3
3exg chain 5
3exg chain A
3exg chain C
3exg chain E
3exg chain G
3exg chain I
3exg chain K
3exg chain M
3exg chain O
3exg chain Q
3exg chain S
3exg chain U
3exg chain W
3exg chain Y
3exh chain A
3exh chain C
3exh chain E
3exh chain G
3exi chain A
6cer chain A
6cer chain C
6cer chain E
6cer chain G
6cfo chain A
6cfo chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T231 NNRYGMGT SVERAAA 7 282 - - 91 70 14 30 27 - - - 10 9 8 8 7 1 - - 7 - S232 NRYGMGTS VERAAAS 10 1524 104 - 103 80 97 100 99 - 108 62 108 99 105 95 83 19 105 44 95 18 Y242 RAAASTDY YKRGDFI 7 114 8 - 11 3 4 5 27 - 17 12 5 5 - - 13 4 - - - - S331 MVNSNLAS VEELKEI 2 39 - - 16 15 - - - - - - - - 4 4 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T231 NNRYGMGT SVERAAA 6e-22 - 6.1e-22 - - - - - - - - S232 NRYGMGTS VERAAAS -8.2e-5 - -0.053 -8e-14 - -3.3e-16 4e-10 5.8e-9 -0.31 -4.8e-16 4.9e-4 Y242 RAAASTDY YKRGDFI - - - - - - - - - - - S331 MVNSNLAS VEELKEI - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T231
S232
Y242
S331
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T231 S232 Y242 S331 protein RNA SCNV methylation CCRCC T231 S232 Y242 S331 protein RNA SCNV methylation COAD T231 S232 Y242 S331 protein RNA SCNV methylation GBM T231 S232 Y242 S331 protein RNA SCNV methylation HNSCC T231 S232 Y242 S331 protein RNA SCNV methylation LSCC T231 S232 Y242 S331 protein RNA SCNV methylation LUAD T231 S232 Y242 S331 protein RNA SCNV methylation OV T231 S232 Y242 S331 protein RNA SCNV methylation PDAC T231 S232 Y242 S331 protein RNA SCNV methylation UCEC T231 S232 Y242 S331 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T231
S232
Y242
S331
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T231
S232
Y242
S331
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.