PDZK1: PDZ domain containing 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2eei chain A
2eej chain A
2vsp chain A
2vsp chain B
2vsp chain C
2vsp chain D
3tmh chain A
3tmh chain E
3tmh chain I
4q2p chain A
4q2p chain B
4q2p chain C
6ezi chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S81 LVRKSGNS VTLLVLD 1 112 - - 61 51 - - - - - - - - - - - - - - - - T83 RKSGNSVT LLVLDGD 1 25 - - 13 12 - - - - - - - - - - - - - - - - S108 DLKELGQS QKEQGLS 1 73 - - 38 35 - - - - - - - - - - - - - - - - S115 SQKEQGLS DNILSPV 1 48 - - 26 22 - - - - - - - - - - - - - - - - S120 GLSDNILS PVMNGGV 4 318 29 - 103 80 - - - - - - - - - - - - 67 31 6 2 S148 EGGSYGFS LKTVQGK 1 175 - - 99 76 - - - - - - - - - - - - - - - - S233 QFKRETAS LKLLPHQ 1 13 - - - - - - - - - - - - - - - - 10 3 - - S250 IVEMKKGS NGYGFYL 1 46 - - 23 23 - - - - - - - - - - - - - - - - S275 IKDIDSGS PAEEAGL 2 29 21 - 4 4 - - - - - - - - - - - - - - - - S316 RKGGDQTS LLVVDKE 1 68 - - 36 32 - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S81 LVRKSGNS VTLLVLD -9.3e-18 - -9.3e-18 - - - - - - - - T83 RKSGNSVT LLVLDGD - - - - - - - - - - - S108 DLKELGQS QKEQGLS -8e-10 - -8e-10 - - - - - - - - S115 SQKEQGLS DNILSPV -0.93 - -0.93 - - - - - - - - S120 GLSDNILS PVMNGGV -3.6e-6 - -0.56 - - - - - - -2.4e-9 - S148 EGGSYGFS LKTVQGK -1.4e-23 - -1.4e-23 - - - - - - - - S233 QFKRETAS LKLLPHQ - - - - - - - - - - - S250 IVEMKKGS NGYGFYL -1.1e-11 - -1.1e-11 - - - - - - - - S275 IKDIDSGS PAEEAGL - - - - - - - - - - - S316 RKGGDQTS LLVVDKE -2.7e-9 - -2.7e-9 - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S81
T83
S108
S115
S120
S148
S233
S250
S275
S316
Y339
S341
T356
T358
S359
S363
S364
S401
S473
T480
S484
S492
S496
S511
S512
S514
T517
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation CCRCC S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation COAD S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation GBM S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation HNSCC S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation LSCC S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation LUAD S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation OV S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation PDAC S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation UCEC S81 T83 S108 S115 S120 S148 S233 S250 S275 S316 Y339 S341 T356 T358 S359 S363 S364 S401 S473 T480 S484 S492 S496 S511 S512 S514 T517 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S81
T83
S108
S115
S120
S148
S233
S250
S275
S316
Y339
S341
T356
T358
S359
S363
S364
S401
S473
T480
S484
S492
S496
S511
S512
S514
T517
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S81
T83
S108
S115
S120
S148
S233
S250
S275
S316
Y339
S341
T356
T358
S359
S363
S364
S401
S473
T480
S484
S492
S496
S511
S512
S514
T517
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.