Protein: ENSP00000396493
Gene: PAM

LinkedOmicsKB © 2022-2023 Zhang Lab

PAM:
peptidylglycine alpha-amidating monooxygenase

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S418NPTEKAESESDLVAE18------------------53
S844KMENKPTSSELQKMQ231----------------1786-
S918GRFRGKGSGGLNLGN9708--2424787499-5232191713922392379518
S929NLGNFFASRKGYSRK8590--8368--89-731515635627652236716
S942RKGFDRLSTEGSDQE842515-3128--81-54543127--6630899
T943KGFDRLSTEGSDQEK719625-3128--9-44--3532--74125
S946DRLSTEGSDQEKEDD8115766-9580--99-10862108999788--100429518
S955QEKEDDGSESEEEYS7424--4039--90-211614122725--873869
S957KEDDGSESEEEYSAP739015-4039--64---14122725--5927617
Y961GSESEEEYSAPLPAL199-------------------
Showing 1 to 10 of 11 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S418NPTEKAESESDLVAE-----------
S844KMENKPTSSELQKMQ-----------
S918GRFRGKGSGGLNLGN1.4e-10-0.594.1e-4-3.8e-5---2.9e-70.31
S929NLGNFFASRKGYSRK0.34--0.33----3e-14--1.3e-5-0.72
S942RKGFDRLSTEGSDQE0.35-0.019----8.1e-4--4.9e-5-
T943KGFDRLSTEGSDQEK1.2e-5-0.019----1.2e-4---
S946DRLSTEGSDQEKEDD0.11-0.028--0.540.878.1e-22--5e-13-0.16
S955QEKEDDGSESEEEYS-2.1e-3-0.7---3.7e-3-0.41--8.3e-6-
S957KEDDGSESEEEYSAP-0.21-0.7----0.41--7.3e-4-
Y961GSESEEEYSAPLPAL-----------
Showing 1 to 10 of 11 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationCCRCCS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationCOADS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationGBMS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationHNSCCS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationLSCCS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationLUADS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationOVS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationPDACS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylationUCECS418S844S918S929S942T943S946S955S957Y961S962proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.