CDK12: cyclin dependent kinase 12
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4cxa chain A
4cxa chain C
4nst chain A
4nst chain C
4un0 chain C
4un0 chain D
5acb chain C
5acb chain D
6b3e chain A
6b3e chain C
6ckx chain A
6ckx chain C
6td3 chain B
6td3 chain E
6td3 chain H
7nxk chain A
7nxk chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S14 HGGKKDGS GGASGTL 3 26 - - - - - - 8 - - - 5 5 - - - - - - 6 2 S18 KDGSGGAS GTLQPSS 2 14 - - 4 4 - - - - - - - - - - - - - - 6 - S24 ASGTLQPS SGGGSSN 7 112 24 - 20 20 - - - - 4 4 5 5 8 8 6 2 4 2 - - S29 QPSSGGGS SNSRERH 1 7 - - - - - - - - - - - - - - - - - - 7 - S30 PSSGGGSS NSRERHR 1 18 - - - - 9 9 - - - - - - - - - - - - - - S32 SGGGSSNS RERHRLV 3 122 - - - - 9 9 - - - - - - - - 26 6 - - 56 16 T57 SKDMGLVT PEAASLG 8 1026 79 - 91 68 - - 54 - 89 53 98 90 110 97 - - 65 25 89 18 S78 VEYDDISS DSDTFSD 1 8 - - - - - - - - - - - - - - - - - - 5 3 S80 YDDISSDS DTFSDDM 1 8 - - - - - - - - - - - - - - - - - - 5 3 S102 ENDERRGS DRSDRLH 1 9 - - - - - - - - - - - - 5 4 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S14 HGGKKDGS GGASGTL - - - - - - - - - - - S18 KDGSGGAS GTLQPSS - - - - - - - - - - - S24 ASGTLQPS SGGGSSN 0.014 - 0.014 - - - - - - - - S29 QPSSGGGS SNSRERH - - - - - - - - - - - S30 PSSGGGSS NSRERHR - - - - - - - - - - - S32 SGGGSSNS RERHRLV 0.61 - - - - - - - - - 0.61 T57 SKDMGLVT PEAASLG 0.076 - 0.4 - - -2.2e-13 1.2e-14 3.8e-22 - -6.3e-3 -0.018 S78 VEYDDISS DSDTFSD - - - - - - - - - - - S80 YDDISSDS DTFSDDM - - - - - - - - - - - S102 ENDERRGS DRSDRLH - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S14
S18
S24
S29
S30
S32
T57
S78
S80
S102
S105
S133
S154
S215
S220
S222
S228
S230
S231
S236
S238
S241
Y242
Y246
S249
S253
S256
S257
S265
S274
S276
S288
T289
S291
S293
Y295
S296
S301
S303
S310
S311
S312
S318
Y319
S320
S323
S325
S332
S333
S334
S341
S343
S345
S355
S357
S359
S382
S383
S385
S393
S423
S456
T514
S614
S644
T662
T667
S681
S685
T692
S889
Y892
T893
S1053
T1074
S1075
S1082
S1083
S1226
S1236
T1244
T1246
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation CCRCC S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation COAD S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation GBM S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation HNSCC S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation LSCC S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation LUAD S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation OV S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation PDAC S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation UCEC S14 S18 S24 S29 S30 S32 T57 S78 S80 S102 S105 S133 S154 S215 S220 S222 S228 S230 S231 S236 S238 S241 Y242 Y246 S249 S253 S256 S257 S265 S274 S276 S288 T289 S291 S293 Y295 S296 S301 S303 S310 S311 S312 S318 Y319 S320 S323 S325 S332 S333 S334 S341 S343 S345 S355 S357 S359 S382 S383 S385 S393 S423 S456 T514 S614 S644 T662 T667 S681 S685 T692 S889 Y892 T893 S1053 T1074 S1075 S1082 S1083 S1226 S1236 T1244 T1246 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S14
S18
S24
S29
S30
S32
T57
S78
S80
S102
S105
S133
S154
S215
S220
S222
S228
S230
S231
S236
S238
S241
Y242
Y246
S249
S253
S256
S257
S265
S274
S276
S288
T289
S291
S293
Y295
S296
S301
S303
S310
S311
S312
S318
Y319
S320
S323
S325
S332
S333
S334
S341
S343
S345
S355
S357
S359
S382
S383
S385
S393
S423
S456
T514
S614
S644
T662
T667
S681
S685
T692
S889
Y892
T893
S1053
T1074
S1075
S1082
S1083
S1226
S1236
T1244
T1246
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S14
S18
S24
S29
S30
S32
T57
S78
S80
S102
S105
S133
S154
S215
S220
S222
S228
S230
S231
S236
S238
S241
Y242
Y246
S249
S253
S256
S257
S265
S274
S276
S288
T289
S291
S293
Y295
S296
S301
S303
S310
S311
S312
S318
Y319
S320
S323
S325
S332
S333
S334
S341
S343
S345
S355
S357
S359
S382
S383
S385
S393
S423
S456
T514
S614
S644
T662
T667
S681
S685
T692
S889
Y892
T893
S1053
T1074
S1075
S1082
S1083
S1226
S1236
T1244
T1246
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.