NFRKB: nuclear factor related to kappaB binding protein
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3u21 chain A
3u21 chain B
4uf5 chain B
4uf6 chain C
4uf6 chain F
4uf6 chain I
4uf6 chain L
4wlp chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S176 PFRQKRPS PSRTPEE 10 694 104 - 16 15 16 20 98 - 61 37 54 49 25 23 6 1 86 36 34 13 S178 RQKRPSPS RTPEERE 4 39 - - 4 4 9 9 - - - - - - - - 6 1 - - 6 - T180 KRPSPSRT PEEREWR 4 90 - - - - - - - - 7 3 5 5 - - - - 13 3 45 9 S209 ECGDTALS SDEEDLS 9 557 57 - 25 22 50 49 9 - 21 15 74 66 54 50 - - 7 3 48 7 S210 CGDTALSS DEEDLSS 9 293 57 - 25 22 50 49 9 - 21 15 5 5 4 4 - - 7 3 12 5 S222 LSSWLPSS PARSPSP 2 33 - - - - 12 15 - - - - - - - - - - - - 6 - S226 LPSSPARS PSPAVPL 5 125 - - - - 4 5 - - - - 14 14 4 3 29 4 - - 34 14 S228 SSPARSPS PAVPLRV 9 976 25 - - - 90 90 81 - 45 26 65 60 97 89 83 19 73 26 89 18 S298 VNAGRKGS LAALYDL 10 965 6 - 54 52 82 71 99 - 90 52 58 50 53 45 7 1 102 42 83 18 S339 DLAEPLSS TEGVAPL 1 9 - - - - - - - - - - - - - - - - - - - 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S176 PFRQKRPS PSRTPEE 0.074 - - - - 9e-10 3.9e-10 -0.37 - -1.8e-7 -0.023 S178 RQKRPSPS RTPEERE - - - - - - - - - - - T180 KRPSPSRT PEEREWR - - - - - - - - - - - S209 ECGDTALS SDEEDLS -2.2e-3 - -0.23 0.73 - -0.34 -0.33 -4.8e-5 - - - S210 CGDTALSS DEEDLSS -0.3 - -0.23 0.73 - -0.34 - - - - - S222 LSSWLPSS PARSPSP - - - - - - - - - - - S226 LPSSPARS PSPAVPL 3.4e-5 - - - - - - - - - 3.4e-5 S228 SSPARSPS PAVPLRV -0.026 - - 1.0e-6 - 0.9 9.2e-4 -1.2e-15 0.47 2.2e-5 0.57 S298 VNAGRKGS LAALYDL 6.1e-16 - 6.4e-8 5e-7 - -0.031 1.4e-10 3.4e-8 - 0.049 -0.44 S339 DLAEPLSS TEGVAPL - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S176
S178
T180
S209
S210
S222
S226
S228
S298
S339
T340
S347
S351
S494
S495
T498
T499
S711
S736
S765
T768
S797
S799
S887
S896
T899
T1035
T1151
T1288
S1291
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation CCRCC S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation COAD S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation GBM S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation HNSCC S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation LSCC S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation LUAD S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation OV S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation PDAC S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation UCEC S176 S178 T180 S209 S210 S222 S226 S228 S298 T340 S347 S351 S494 S495 T498 T499 S711 S736 S765 T768 S797 S799 S887 S896 T899 T1035 T1151 T1288 S1291 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S176
S178
T180
S209
S210
S222
S226
S228
S298
S339
T340
S347
S351
S494
S495
T498
T499
S711
S736
S765
T768
S797
S799
S887
S896
T899
T1035
T1151
T1288
S1291
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S176
S178
T180
S209
S210
S222
S226
S228
S298
S339
T340
S347
S351
S494
S495
T498
T499
S711
S736
S765
T768
S797
S799
S887
S896
T899
T1035
T1151
T1288
S1291
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.