NEK1: NIMA related kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4apc chain A
4apc chain B
4b9d chain A
4b9d chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S267 KRIEKFLS PQLIAEE 1 9 - - - - - - 9 - - - - - - - - - - - - - S285 KTFSKFGS QPIPAKR 5 260 8 - 62 43 - - 18 - - - - - 55 49 - - - - 25 - S299 RPASGQNS ISVMPAQ 4 42 8 - - - - - 9 - - - 5 5 - - - - 9 6 - - S301 ASGQNSIS VMPAQKI 2 63 53 - - - - - - - - - 5 5 - - - - - - - - T344 KHKQAHQT PEKRVNT 3 25 - - - - - - 10 - - - 4 4 - - 6 1 - - - - S359 GEERRKIS EEAARKR 3 57 - - 20 10 - - 9 - - - - - - - - - 12 6 - - S414 QGWRNVLS AGGSGEV 10 946 46 - 59 37 20 16 90 - 102 58 58 54 52 49 52 9 105 44 77 18 S418 NVLSAGGS GEVKAPF 9 811 54 - 88 65 - - 73 - 33 19 35 31 105 97 7 2 72 29 83 18 S428 VKAPFLGS GGTIAPS 1 16 - - - - - - - - - - - - - - - - - - 12 4 S435 SGGTIAPS SFSSRGQ 2 17 - - - - - - - - 6 3 - - - - 7 1 - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S267 KRIEKFLS PQLIAEE - - - - - - - - - - - S285 KTFSKFGS QPIPAKR 9e-8 - 8.6e-9 - - - - 0.071 - - - S299 RPASGQNS ISVMPAQ - - - - - - - - - - - S301 ASGQNSIS VMPAQKI - - - - - - - - - - - T344 KHKQAHQT PEKRVNT - - - - - - - - - - - S359 GEERRKIS EEAARKR 0.85 - 0.85 - - - - - - - - S414 QGWRNVLS AGGSGEV -3.5e-4 - 9.6e-13 -0.039 - -0.47 -5.5e-10 -0.023 - -0.93 -1.6e-7 S418 NVLSAGGS GEVKAPF -7e-7 - 3.1e-17 - - -5.1e-3 -3.9e-10 -7.2e-6 - -0.019 -7.6e-6 S428 VKAPFLGS GGTIAPS - - - - - - - - - - - S435 SGGTIAPS SFSSRGQ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S267
S285
S299
S301
T344
S359
S414
S418
S428
S435
S436
S589
S653
T661
S664
S675
T735
S798
S806
S837
S857
S863
S868
T872
S874
S881
S885
S914
S925
S1008
S1030
T1050
S1052
S1092
S1094
S1126
S1131
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation CCRCC S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation COAD S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation GBM S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation HNSCC S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation LSCC S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation LUAD S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation OV S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation PDAC S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation UCEC S267 S285 S299 S301 T344 S359 S414 S418 S428 S435 S436 S589 S653 T661 S664 S675 T735 S798 S806 S837 S857 S863 S868 T872 S874 S881 S885 S914 S925 S1008 S1030 T1050 S1052 S1092 S1094 S1126 S1131 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S267
S285
S299
S301
T344
S359
S414
S418
S428
S435
S436
S589
S653
T661
S664
S675
T735
S798
S806
S837
S857
S863
S868
T872
S874
S881
S885
S914
S925
S1008
S1030
T1050
S1052
S1092
S1094
S1126
S1131
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S267
S285
S299
S301
T344
S359
S414
S418
S428
S435
S436
S589
S653
T661
S664
S675
T735
S798
S806
S837
S857
S863
S868
T872
S874
S881
S885
S914
S925
S1008
S1030
T1050
S1052
S1092
S1094
S1126
S1131
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.