Protein: ENSP00000411099
Gene: TLK1

LinkedOmicsKB © 2022-2023 Zhang Lab

TLK1:
tousled like kinase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S33GSAAAARSLLNHTPP6373--3727--9-4525--4943--53195016
T38ARSLLNHTPPSGRPR7972--7469--89-96541089910696--78305716
S54GAMDELHSLDPRRQE16------------------6-
S74FTGVASGSTGSTGSC17------------------7-
T75TGVASGSTGSTGSCS331------------45--42142
S77VASGSTGSTGSCSVG7435--5037--9-221460545043--2913477
T78ASGSTGSTGSCSVGA7269--1716--9-63997365--208313
S80GSTGSTGSCSVGAKA216------10---------51--
S82TGSTGSCSVGAKAST18------------------53
S94ASTNNESSNHSFGSL5287------73-794515141916----224
Showing 1 to 10 of 24 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S33GSAAAARSLLNHTPP-0.26-0.012--0.035--0.49--7.3e-3-1.8e-4
T38ARSLLNHTPPSGRPR2.7e-10--0.12--1.4e-157.2e-57e-9--2.5e-66.9e-5
S54GAMDELHSLDPRRQE-----------
S74FTGVASGSTGSTGSC-----------
T75TGVASGSTGSTGSCS-----------
S77VASGSTGSTGSCSVG4.1e-10--1.3e-5--2.9e-66.4e-141.1e-12--0.35-
T78ASGSTGSTGSCSVGA1.2e-11------1.2e-11---
S80GSTGSTGSCSVGAKA-----------
S82TGSTGSCSVGAKAST-----------
S94ASTNNESSNHSFGSL3.9e-12----3.8e-12-----
Showing 1 to 10 of 24 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationCCRCCS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationCOADS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationGBMS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationHNSCCS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationLSCCS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationLUADS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationOVS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationPDACS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylationUCECS33T38S54S74T75S77T78S80S82S94S97S105S133S134Y152S158S159S188S190S741S743S744S755proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.