MARK3: microtubule affinity regulating kinase 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2qnj chain A
2qnj chain B
3fe3 chain A
3fe3 chain B
7p1l chain A
7p1l chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S42 SGARCRNS IASCADE 9 537 14 - 16 8 - - 90 - 23 13 5 5 40 37 70 15 74 31 78 18 S45 RCRNSIAS CADEQPH 8 166 14 - 4 4 - - 18 - 5 4 30 28 5 4 34 10 - - 6 - S341 IMVGMGYS QEEIQES 5 219 22 - 5 4 - - 72 - - - 25 23 36 32 - - - - - - S368 YLLLGRKS SELDASD 1 14 - - - - - - - - - - - - - - - - - - 12 2 S369 LLLGRKSS ELDASDS 4 137 - - - - - - 82 - - - - - 4 4 - - 4 1 36 6 S374 KSSELDAS DSSSSSN 5 179 - - - - - - 55 - 6 3 24 23 5 4 - - - - 50 9 S376 SELDASDS SSSSNLS 2 19 - - - - - - - - 6 4 - - 5 4 - - - - - - S377 ELDASDSS SSSNLSL 9 103 24 - 4 4 4 5 9 - 5 3 5 4 9 8 - - 4 1 12 2 S378 LDASDSSS SSNLSLA 10 873 92 - 54 41 43 38 82 - 79 46 68 62 25 24 30 5 59 25 82 18 S379 DASDSSSS SNLSLAK 6 84 9 - 4 4 - - - - 12 5 10 9 13 12 - - - - 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S42 SGARCRNS IASCADE -0.73 - - - - 0.9 - -2.1e-5 0.061 1.8e-4 -0.023 S45 RCRNSIAS CADEQPH -0.2 - - - - - -0.18 - -0.63 - - S341 IMVGMGYS QEEIQES -2.1e-12 - - - - - -3.5e-5 -6.6e-9 - - - S368 YLLLGRKS SELDASD - - - - - - - - - - - S369 LLLGRKSS ELDASDS - - - - - - - - - - - S374 KSSELDAS DSSSSSN -0.017 - - - - - -0.017 - - - - S376 SELDASDS SSSSNLS - - - - - - - - - - - S377 ELDASDSS SSSNLSL - - - - - - - - - - - S378 LDASDSSS SSNLSLA 7.6e-4 - -6.0e-4 -1.3e-3 - 1.5e-14 2.4e-5 -0.59 - 1.1e-3 0.36 S379 DASDSSSS SNLSLAK - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S42
S45
S341
S368
S369
S374
S376
S377
S378
S379
S380
S383
S390
S391
S396
T397
S400
S410
S412
Y418
S419
S436
T438
S439
S451
S452
S456
S469
S489
T491
S499
T507
S520
T536
S540
T541
S543
S545
S546
T549
S563
T564
T576
S583
S585
S587
S598
S601
T627
S639
S643
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation CCRCC S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation COAD S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation GBM S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation HNSCC S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation LSCC S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation LUAD S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation OV S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation PDAC S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation UCEC S42 S45 S341 S368 S369 S374 S376 S377 S378 S379 S380 S383 S390 S391 S396 T397 S400 S410 S412 Y418 S419 S436 T438 S439 S451 S452 S456 S469 S489 T491 S499 T507 S520 T536 S540 T541 S543 S545 S546 T549 S563 T564 T576 S583 S585 S587 S598 S601 T627 S639 S643 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S42
S45
S341
S368
S369
S374
S376
S377
S378
S379
S380
S383
S390
S391
S396
T397
S400
S410
S412
Y418
S419
S436
T438
S439
S451
S452
S456
S469
S489
T491
S499
T507
S520
T536
S540
T541
S543
S545
S546
T549
S563
T564
T576
S583
S585
S587
S598
S601
T627
S639
S643
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S42
S45
S341
S368
S369
S374
S376
S377
S378
S379
S380
S383
S390
S391
S396
T397
S400
S410
S412
Y418
S419
S436
T438
S439
S451
S452
S456
S469
S489
T491
S499
T507
S520
T536
S540
T541
S543
S545
S546
T549
S563
T564
T576
S583
S585
S587
S598
S601
T627
S639
S643
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.