TOP2A: DNA topoisomerase II alpha
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1zxm chain A
1zxm chain B
1zxn chain A
1zxn chain B
1zxn chain C
1zxn chain D
4fm9 chain A
4r1f chain A
4r1f chain B
4r1f chain C
4r1f chain D
5gwk chain A
5gwk chain B
5nne chain C
6zy5 chain A
6zy5 chain B
6zy6 chain A
6zy6 chain B
6zy7 chain A
6zy7 chain B
6zy8 chain A
6zy8 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y841 QRVEPEWY IPIIPMV 1 9 - - - - - - - - - - - - - - - - 6 3 - - S861 EGIGTGWS CKIPNFD 1 9 - - - - - - - - - - - - - - - - 6 3 - - S1106 DEEENEES DNEKETE 10 1539 122 - 99 77 97 100 99 - 108 62 108 99 110 95 83 19 104 44 95 18 S1115 NEKETEKS DSVTDSG 2 25 - - 4 4 - - 17 - - - - - - - - - - - - - S1117 KETEKSDS VTDSGPT 1 7 - - 4 3 - - - - - - - - - - - - - - - - S1213 QMAEVLPS PRGQRVI 10 1442 122 - 52 35 95 93 99 - 108 62 108 99 110 101 83 19 101 42 95 18 T1244 KKIKNENT EGSPQED 2 18 6 - - - - - - - - - - - - - - - - - 12 - S1247 KNENTEGS PQEDGVE 10 1429 122 - 52 40 97 100 99 - 108 62 108 88 110 100 76 16 101 42 90 18 S1295 GKKRNPWS DSESDRS 1 6 - - - - - - - - - - - - - - - - 5 1 - - S1332 KFTMDLDS DEDFSDF 9 279 6 - 12 12 11 7 9 - 6 3 69 62 13 12 - - 6 4 38 9
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y841 QRVEPEWY IPIIPMV - - - - - - - - - - - S861 EGIGTGWS CKIPNFD - - - - - - - - - - - S1106 DEEENEES DNEKETE 2.1e-97 - 5.5e-14 1.1e-29 - 1.1e-16 5.2e-31 3.6e-26 4.1e-5 3.7e-10 -0.67 S1115 NEKETEKS DSVTDSG - - - - - - - - - - - S1117 KETEKSDS VTDSGPT - - - - - - - - - - - S1213 QMAEVLPS PRGQRVI 4.5e-62 - 1.3e-4 9.6e-7 - 1.7e-18 2.9e-29 3.2e-10 1.8e-3 6.7e-10 6.9e-3 T1244 KKIKNENT EGSPQED - - - - - - - - - - - S1247 KNENTEGS PQEDGVE 5.5e-95 - 2.2e-3 1.7e-29 - 3.6e-15 4.5e-28 1.2e-26 4.6e-5 6.6e-13 8.3e-4 S1295 GKKRNPWS DSESDRS - - - - - - - - - - - S1332 KFTMDLDS DEDFSDF 3.7e-9 - - - - - 3.7e-9 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
Y841
S861
S1106
S1115
S1117
S1213
T1244
S1247
S1295
S1332
S1337
T1343
S1351
S1354
S1361
S1365
S1374
S1377
S1392
S1393
T1397
T1403
S1449
S1469
T1470
S1471
S1474
S1476
S1495
S1504
S1525
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation CCRCC Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation COAD Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation GBM Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation HNSCC Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation LSCC Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation LUAD Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation OV Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation PDAC Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation UCEC Y841 S861 S1106 S1115 S1117 S1213 T1244 S1247 S1295 S1332 S1337 T1343 S1351 S1354 S1361 S1365 S1374 S1377 S1392 S1393 T1397 T1403 S1449 S1469 T1470 S1471 S1474 S1476 S1495 S1504 S1525 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
Y841
S861
S1106
S1115
S1117
S1213
T1244
S1247
S1295
S1332
S1337
T1343
S1351
S1354
S1361
S1365
S1374
S1377
S1392
S1393
T1397
T1403
S1449
S1469
T1470
S1471
S1474
S1476
S1495
S1504
S1525
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
Y841
S861
S1106
S1115
S1117
S1213
T1244
S1247
S1295
S1332
S1337
T1343
S1351
S1354
S1361
S1365
S1374
S1377
S1392
S1393
T1397
T1403
S1449
S1469
T1470
S1471
S1474
S1476
S1495
S1504
S1525
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.