NCK1: NCK adaptor protein 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ci8 chain A
2ci9 chain A
2ci9 chain B
2cub chain A
2js0 chain A
2js2 chain A
2jw4 chain A
5qu1 chain A
5qu1 chain B
5qu2 chain A
5qu2 chain B
5qu3 chain A
5qu3 chain B
5qu4 chain A
5qu4 chain B
5qu4 chain C
5qu4 chain D
5qu5 chain A
5qu5 chain B
5qu6 chain 1
5qu6 chain 2
5qu6 chain A
5qu6 chain B
5qu6 chain C
5qu6 chain D
5qu6 chain E
5qu6 chain F
5qu6 chain G
5qu6 chain H
5qu6 chain I
5qu6 chain J
5qu6 chain K
5qu6 chain L
5qu6 chain M
5qu6 chain N
5qu6 chain O
5qu6 chain P
5qu6 chain Q
5qu6 chain R
5qu6 chain S
5qu6 chain T
5qu6 chain U
5qu6 chain V
5qu6 chain W
5qu6 chain X
5qu6 chain Y
5qu6 chain Z
5qu7 chain A
5qu7 chain B
5qu8 chain A
5qua chain A
5qua chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S44 SWWRVRNS MNKTGFV 2 55 - - - - - - - - - - 10 10 - - - - 26 9 - - S85 GKVKRKPS VPDSASP 9 526 8 - 5 4 64 70 82 - 11 5 15 14 - - 69 13 53 22 76 15 S89 RKPSVPDS ASPADDS 10 932 82 - 95 72 30 50 9 - 108 62 98 90 106 97 6 2 7 2 7 9 S91 PSVPDSAS PADDSFV 10 1060 105 - 87 64 45 62 54 - 99 56 68 61 82 77 20 5 78 33 50 14 S96 SASPADDS FVDPGER 5 167 49 - 12 12 - - - - - - 33 28 - - - - 8 2 19 4 Y105 VDPGERLY DLNMPAY 10 1390 87 - 103 80 80 73 99 - 103 59 98 90 110 101 52 14 91 37 95 18 Y112 YDLNMPAY VKFNYMA 4 81 - - 7 7 - - - - - - - - 13 10 6 2 - - 34 2 S147 SDGWWRGS YNGQVGW 7 189 - - 16 15 - - 9 - 25 13 34 32 15 12 - - 9 4 5 - S157 GQVGWFPS NYVTEEG 5 109 9 - 24 23 3 6 - - 16 10 - - 10 8 - - - - - - Y159 VGWFPSNY VTEEGDS 2 26 - - 12 9 - - - - - - - - - - - - 4 1 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S44 SWWRVRNS MNKTGFV - - - - - - - - - - - S85 GKVKRKPS VPDSASP -2.9e-6 - - -9.8e-16 - - - - -0.96 -0.031 0.38 S89 RKPSVPDS ASPADDS -1.7e-9 - 6.6e-12 -1.7e-7 - -6.3e-5 -2.5e-7 -2.8e-9 - - - S91 PSVPDSAS PADDSFV -0.048 - 2.6e-11 -3.1e-8 - -0.17 0.11 -0.053 - -1.9e-7 0.59 S96 SASPADDS FVDPGER 6.2e-7 - - - - - 6.2e-7 - - - - Y105 VDPGERLY DLNMPAY -3e-55 - -1.8e-5 -1.2e-16 - -1.8e-22 -9e-19 -7.4e-14 -0.17 0.54 -1.2e-6 Y112 YDLNMPAY VKFNYMA - - - - - - - - - - - S147 SDGWWRGS YNGQVGW -1.2e-10 - - - - -8.7e-4 -7.7e-9 - - - - S157 GQVGWFPS NYVTEEG 1.7e-6 - 1.7e-6 - - - - - - - - Y159 VGWFPSNY VTEEGDS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S44
S85
S89
S91
S96
Y105
Y112
S147
S157
Y159
T161
S166
S174
S204
S262
S313
S320
S347
T348
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation CCRCC S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation COAD S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation GBM S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation HNSCC S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation LSCC S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation LUAD S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation OV S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation PDAC S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation UCEC S44 S85 S89 S91 S96 Y105 Y112 S147 S157 Y159 T161 S166 S174 S204 S262 S313 S320 S347 T348 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S44
S85
S89
S91
S96
Y105
Y112
S147
S157
Y159
T161
S166
S174
S204
S262
S313
S320
S347
T348
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S44
S85
S89
S91
S96
Y105
Y112
S147
S157
Y159
T161
S166
S174
S204
S262
S313
S320
S347
T348
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.