MECOM: MDS1 and EVI1 complex locus
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
6bw3 chain B
6bw3 chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S62 AFTPKEGS PYKAPIY 2 86 - - - - 36 27 - - - - - - - - 22 1 - - - - T234 HQKFPCST PHSAFSM 1 8 - - - - - - - - - - - - - - - - - - 5 3 S237 FPCSTPHS AFSMVEE 1 29 - - - - - - - - - - - - - - - - - - 24 5 S240 STPHSAFS MVEEDFQ 1 29 - - - - - - - - - - - - - - - - - - 24 5 S252 DFQQKLES ENDLQEI 2 99 - - - - - - - - - - - - 5 4 - - - - 72 18 S444 GFFGQGIS LPGTPAM 2 18 - - 4 4 - - - - - - 5 5 - - - - - - - - T448 QGISLPGT PAMDKTS 1 6 - - - - - - - - - - - - - - - - - - 6 - T518 PVKGLSST EQTNKSQ 1 6 - - - - - - - - - - - - - - - - - - 6 - S524 STEQTNKS QSPLMTH 1 34 - - - - - - - - - - - - - - - - - - 31 3 S526 EQTNKSQS PLMTHPQ 7 336 - - 5 4 - - 27 - 18 9 5 5 26 24 - - 70 30 95 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S62 AFTPKEGS PYKAPIY 0.033 - - 0.033 - - - - - - - T234 HQKFPCST PHSAFSM - - - - - - - - - - - S237 FPCSTPHS AFSMVEE - - - - - - - - - - - S240 STPHSAFS MVEEDFQ - - - - - - - - - - - S252 DFQQKLES ENDLQEI 8.5e-5 - - - - - - - - - 8.5e-5 S444 GFFGQGIS LPGTPAM - - - - - - - - - - - T448 QGISLPGT PAMDKTS - - - - - - - - - - - T518 PVKGLSST EQTNKSQ - - - - - - - - - - - S524 STEQTNKS QSPLMTH - - - - - - - - - - - S526 EQTNKSQS PLMTHPQ 0.25 - - - - - - -0.42 - -0.076 5.3e-6
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S62
T234
S237
S240
S252
S444
T448
T518
S524
S526
T530
S550
S624
S631
S726
S737
S738
S740
T755
S759
T764
T767
S1002
S1003
S1006
S1033
S1037
S1039
S1061
S1064
T1112
S1113
S1118
S1122
S1147
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation CCRCC S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation COAD S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation GBM S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation HNSCC S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation LSCC S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation LUAD S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation OV S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation PDAC S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation UCEC S62 T234 S237 S240 S252 S444 T448 T518 S524 S526 T530 S550 S624 S631 S726 S737 S738 S740 T755 S759 T764 T767 S1002 S1003 S1006 S1033 S1037 S1039 S1061 S1064 T1112 S1113 S1118 S1122 S1147 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S62
T234
S237
S240
S252
S444
T448
T518
S524
S526
T530
S550
S624
S631
S726
S737
S738
S740
T755
S759
T764
T767
S1002
S1003
S1006
S1033
S1037
S1039
S1061
S1064
T1112
S1113
S1118
S1122
S1147
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S62
T234
S237
S240
S252
S444
T448
T518
S524
S526
T530
S550
S624
S631
S726
S737
S738
S740
T755
S759
T764
T767
S1002
S1003
S1006
S1033
S1037
S1039
S1061
S1064
T1112
S1113
S1118
S1122
S1147
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.