FHIT: fragile histidine triad diadenosine triphosphatase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1fhi chain A
1fit chain A
2fhi chain A
2fit chain A
3fit chain A
4fit chain A
5fit chain A
6fit chain A
7p8p chain A
7p8p chain B
7p8p chain C
7p8p chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S112 GDFHRNDS IYEELQK 7 245 7 - 54 41 - - 44 - - - 10 10 4 4 - - 4 2 49 16 Y114 FHRNDSIY EELQKHD 2 26 9 - 9 8 - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S112 GDFHRNDS IYEELQK 3.9e-4 - 0.055 - - - - - - - 0.002 Y114 FHRNDSIY EELQKHD - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S112
Y114
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S112 Y114 protein RNA SCNV methylation CCRCC S112 Y114 protein RNA SCNV methylation COAD S112 Y114 protein RNA SCNV methylation GBM S112 Y114 protein RNA SCNV methylation HNSCC S112 Y114 protein RNA SCNV methylation LSCC S112 Y114 protein RNA SCNV methylation LUAD S112 Y114 protein RNA SCNV methylation OV S112 Y114 protein RNA SCNV methylation PDAC S112 Y114 protein RNA SCNV methylation UCEC S112 Y114 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S112
Y114
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S112
Y114
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.