Protein: ENSP00000419711
Gene: EZH2

LinkedOmicsKB © 2022-2023 Zhang Lab

EZH2:
enhancer of zeste 2 polycomb repressive complex 2 subunit

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S362RGRLPNNSSRPSTPT452----45------54--511711
S363GRLPNNSSRPSTPTI1034134-88686618-231144441522482416
S366PNNSSRPSTPTINVL1050767-36336316-108625855872862111-
T367NNSSRPSTPTINVLE101377104-48389710081-1086210394102917616102429518
T369SSRPSTPTINVLESK36121-----------1716----7-
S380LESKDTDSDREAGTE1098489-248303299-7947988475665-98429018
T386DSDREAGTETGGENN51526-------20151513----37132013
T388DREAGTETGGENNDK7163------36-2015994462301018-
S405EEKKDETSSSSEANS148----------2523--------
S406EKKDETSSSSEANSR8144--88--36-63292543713272
Showing 1 to 10 of 16 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S362RGRLPNNSSRPSTPT-----------
S363GRLPNNSSRPSTPTI1e-11--4.5e-15-0.06----0.039
S366PNNSSRPSTPTINVL1.6e-43-8.7e-16--3.3e-135.8e-18----
T367NNSSRPSTPTINVLE1.9e-77-3.5e-62.5e-15-7.9e-111.3e-318.8e-259.9e-56.8e-51.6e-4
T369SSRPSTPTINVLESK-----------
S380LESKDTDSDREAGTE4.7e-43--1.4e-3-1.3e-101.9e-306.2e-24--0.0497.2e-6
T386DSDREAGTETGGENN0.031----0.012---0.18-0.9
T388DREAGTETGGENNDK1.2e-4----0.012---3.5e-3-
S405EEKKDETSSSSEANS2e-7-----2e-7----
S406EKKDETSSSSEANSR8.3e-15-----8.3e-15----
Showing 1 to 10 of 16 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationCCRCCS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationCOADS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationGBMS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationHNSCCS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationLSCCS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationLUADS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationOVS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationPDACS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylationUCECS362S363S366T367T369S380T386T388S405S406S407S408S412T416S474T487proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.