Protein: ENSP00000420494
Gene: LAT2

LinkedOmicsKB © 2022-2023 Zhang Lab

LAT2:
linker for activation of T cells family member 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S44EKIYQQRSLREDQQS1075721-44424863-674168637064681568271311
S51SLREDQQSFTGSRTY1090332-124707373-52299891878142760254918
T53REDQQSFTGSRTYSL126----1214--------------
S55DQQSFTGSRTYSLVG270----1214--------377----
S59FTGSRTYSLVGQAWP10117271-6249515672-905410899101925312101434018
S86KLLQFYPSLEDPASS963321-5030--36-4321898181735011422318
S92PSLEDPASSRYQNFS18--------------62----
S102YQNFSKGSRHGSEEA729582-42504927---292754124----
S106SKGSRHGSEEAYIDP882096-8765363690-12810395958962----
Y110RHGSEEAYIDPIAME118------------108------
Showing 1 to 10 of 18 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S44EKIYQQRSLREDQQS0.78---0.17-1.7e-5-4.0e-60.25-0.450.051-
S51SLREDQQSFTGSRTY3.1e-9--0.68-4.5e-61.3e-42.7e-8-0.077-0.1
T53REDQQSFTGSRTYSL-----------
S55DQQSFTGSRTYSLVG-----------
S59FTGSRTYSLVGQAWP-1.7e-3-5.9e-14-6.3e-5--0.27-8.1e-8-6.8e-6-0.0370.37-0.82
S86KLLQFYPSLEDPASS-2.4e-3-3.7e-7---0.02-2.4e-10-1.5e-4-0.7-0.75
S92PSLEDPASSRYQNFS-----------
S102YQNFSKGSRHGSEEA-6.8e-6---0.021---5.0e-5----
S106SKGSRHGSEEAYIDP-0.033-1.9e-8-1.8e-4---6.6e-8-0.46---
Y110RHGSEEAYIDPIAME-----------
Showing 1 to 10 of 18 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationCCRCCS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationCOADS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationGBMS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationHNSCCS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationLSCCS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationLUADS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationOVS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationPDACS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylationUCECS44S51T53S55S59S86S92S102S106Y110S135Y136S167S205S217S223Y233T241proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.