PDK2: pyruvate dehydrogenase kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2btz chain A
2bu2 chain A
2bu5 chain A
2bu6 chain A
2bu7 chain A
2bu8 chain A
4mp2 chain A
4mp7 chain A
4mpc chain A
4mpe chain A
4mpn chain A
4v25 chain A
4v26 chain A
5j6a chain A
5j71 chain A
5m4k chain A
5m4m chain A
5m4n chain A
5m4p chain A
6lil chain A
6lil chain B
6lin chain A
6lin chain B
6lin chain C
6lin chain D
6lio chain A
6lio chain B
6tmp chain AAA
6tmq chain AAA
6tmz chain AAA
6tn0 chain AAA
6tn2 chain AAA
7ea0 chain A
7eas chain A
7ebh chain A
7vbu chain A
7vbv chain A
7vbv chain B
7vbx chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S395 AGDWCVPS TEPKNTS 1 105 - - 58 47 - - - - - - - - - - - - - - - - S407 NTSTYRVS _______ 1 33 - - 17 16 - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S395 AGDWCVPS TEPKNTS 4.5e-11 - 4.4e-11 - - - - - - - - S407 NTSTYRVS _______ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S395
S407
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S395 S407 protein RNA SCNV methylation CCRCC S395 S407 protein RNA SCNV methylation COAD S395 S407 protein RNA SCNV methylation GBM S395 S407 protein RNA SCNV methylation HNSCC S395 S407 protein RNA SCNV methylation LSCC S395 S407 protein RNA SCNV methylation LUAD S395 S407 protein RNA SCNV methylation OV S395 S407 protein RNA SCNV methylation PDAC S395 S407 protein RNA SCNV methylation UCEC S395 S407 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S395
S407
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S395
S407
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.