Protein: ENSP00000421096
Gene: PAICS

LinkedOmicsKB © 2022-2023 Zhang Lab

PAICS:
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S27EVYELLDSPGKVLLQ101484121-9175918999-1015810895110948219101419118
S107CRRIATGSFLKRNPG10107261-4641323199-694198899790276105447818
S230SQQKDKQSYRDLKEV949039-66456290-17920172319--7332284
T238YRDLKEVTPEGLQMV959163-4436--90-231159554540124528418
S274RVVVLMGSTSDLGHC51109-----54-541514------72
T275VVVLMGSTSDLGHCE18--44----------------
S276VVLMGSTSDLGHCEK51897-4230--90-6455--------
T354VISCPPLTPDWGVQD56816-----27-6455----32--
S370WSSLRLPSGLGCSTV122------22-------------
S412SILNTWISLKQADKK110--------64----------
Showing 1 to 10 of 10 rows

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S27EVYELLDSPGKVLLQ1.3e-96-3.4e-127.7e-19-9.9e-182.9e-331.4e-290.0331e-92.2e-3
S107CRRIATGSFLKRNPG1.7e-22-3e-9-0.54-6.3e-42.6e-250.72-4.4e-70.21
S230SQQKDKQSYRDLKEV5.0e-4--5.1e-3---3.5e-62.6e-8--0.65-
T238YRDLKEVTPEGLQMV1.8e-25-0.01--1.9e-47.4e-121.1e-15--0.031
S274RVVVLMGSTSDLGHC-----------
T275VVVLMGSTSDLGHCE-----------
S276VVLMGSTSDLGHCEK-0.038--0.038--------
T354VISCPPLTPDWGVQD-----------
S370WSSLRLPSGLGCSTV-----------
S412SILNTWISLKQADKK-----------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationCCRCCS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationCOADS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationGBMS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationHNSCCS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationLSCCS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationLUADS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationOVS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationPDACS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylationUCECS27S107S230T238S274T275S276T354S370S412proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.